1wjm

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[[Image:1wjm.jpg|left|200px]]
 
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{{Structure
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==Solution structure of pleckstrin homology domain of human beta III spectrin.==
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|PDB= 1wjm |SIZE=350|CAPTION= <scene name='initialview01'>1wjm</scene>
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<StructureSection load='1wjm' size='340' side='right'caption='[[1wjm]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1wjm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WJM FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= KAZUSA cDNA hf00409 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wjm OCA], [https://pdbe.org/1wjm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wjm RCSB], [https://www.ebi.ac.uk/pdbsum/1wjm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wjm ProSAT], [https://www.topsan.org/Proteins/RSGI/1wjm TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Disease ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wjm OCA], [http://www.ebi.ac.uk/pdbsum/1wjm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wjm RCSB]</span>
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[https://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN] Defects in SPTBN2 are the cause of spinocerebellar ataxia type 5 (SCA5) [MIM:[https://omim.org/entry/600224 600224]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA5 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder with variable age at onset, ranging between 10 and 50 years.<ref>PMID:16429157</ref>
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/SPTN2_HUMAN SPTN2_HUMAN] Probably plays an important role in neuronal membrane skeleton.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wj/1wjm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wjm ConSurf].
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<div style="clear:both"></div>
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'''Solution structure of pleckstrin homology domain of human beta III spectrin.'''
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==See Also==
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*[[Spectrin 3D structures|Spectrin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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1WJM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WJM OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Koshiba, S.]]
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[[Category: Koshiba S]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Sato M]]
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[[Category: Sato, M.]]
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[[Category: Tochio N]]
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[[Category: Tochio, N.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: brain 2]]
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[[Category: kiaa0302]]
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[[Category: ph domain]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: signal transduction]]
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[[Category: spectrin beta chain]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:37:09 2008''
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Current revision

Solution structure of pleckstrin homology domain of human beta III spectrin.

PDB ID 1wjm

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Proteopedia Page Contributors and Editors (what is this?)

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