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| - | | + | #REDIRECT [[6cq6]] This PDB entry is obsolete and replaced by 6cq6 |
| - | ==K2P2.1(TREK-1) apo structure==
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| - | <StructureSection load='5vk5' size='340' side='right' caption='[[5vk5]], [[Resolution|resolution]] 3.10Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[5vk5]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5VK5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5VK5 FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=R16:HEXADECANE'>R16</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5vkn|5vkn]], [[5vkp|5vkp]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5vk5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5vk5 OCA], [http://pdbe.org/5vk5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5vk5 RCSB], [http://www.ebi.ac.uk/pdbsum/5vk5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5vk5 ProSAT]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/KCNK2_MOUSE KCNK2_MOUSE]] Ion channel that contributes to passive transmembrane potassium transport. Reversibly converts between a voltage-insensitive potassium leak channel and a voltage-dependent outward rectifying potassium channel in a phosphorylation-dependent manner. In astrocytes, forms mostly heterodimeric potassium channels with KCNK1, with only a minor proportion of functional channels containing homodimeric KCNK2 (PubMed:24496152). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (PubMed:24496152).<ref>PMID:10321245</ref> <ref>PMID:16636285</ref> <ref>PMID:24496152</ref> <ref>PMID:9003761</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Lolicato, M]]
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| - | [[Category: Minor, D L]]
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| - | [[Category: Transport protein]]
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| - | [[Category: Trek-1 ion channel k2p]]
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