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5ue9

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==WT DHODB with orotate bound==
==WT DHODB with orotate bound==
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<StructureSection load='5ue9' size='340' side='right' caption='[[5ue9]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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<StructureSection load='5ue9' size='340' side='right'caption='[[5ue9]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ue9]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UE9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UE9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ue9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactococcus_lactis_subsp._lactis Lactococcus lactis subsp. lactis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UE9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(NAD(+)) Dihydroorotate dehydrogenase (NAD(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.14 1.3.1.14] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FES:FE2/S2+(INORGANIC)+CLUSTER'>FES</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ue9 OCA], [http://pdbe.org/5ue9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ue9 RCSB], [http://www.ebi.ac.uk/pdbsum/5ue9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ue9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ue9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ue9 OCA], [https://pdbe.org/5ue9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ue9 RCSB], [https://www.ebi.ac.uk/pdbsum/5ue9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ue9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0V8EGX5_LACLL A0A0V8EGX5_LACLL]] Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).[HAMAP-Rule:MF_01211]
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[https://www.uniprot.org/uniprot/PYRDB_LACLA PYRDB_LACLA] Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pompeu, Y A]]
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[[Category: Lactococcus lactis subsp. lactis]]
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[[Category: Stewart, J D]]
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[[Category: Large Structures]]
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[[Category: Dehydrogenase]]
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[[Category: Pompeu YA]]
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[[Category: Electron transfer]]
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[[Category: Stewart JD]]
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[[Category: Fes cluster]]
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[[Category: Orotate]]
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[[Category: Oxidoreductase]]
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[[Category: Protein engineering]]
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[[Category: Pyrimidine biosynthesis]]
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Current revision

WT DHODB with orotate bound

PDB ID 5ue9

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