1wnh

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[[Image:1wnh.gif|left|200px]]
 
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{{Structure
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==Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)==
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|PDB= 1wnh |SIZE=350|CAPTION= <scene name='initialview01'>1wnh</scene>, resolution 1.83&Aring;
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<StructureSection load='1wnh' size='340' side='right'caption='[[1wnh]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1wnh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WNH FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.83&#8491;</td></tr>
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|GENE= LXN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wnh OCA], [https://pdbe.org/1wnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wnh RCSB], [https://www.ebi.ac.uk/pdbsum/1wnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wnh ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wnh OCA], [http://www.ebi.ac.uk/pdbsum/1wnh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wnh RCSB]</span>
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[https://www.uniprot.org/uniprot/LXN_MOUSE LXN_MOUSE] Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation.
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wn/1wnh_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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Latexin, the only known mammalian carboxypeptidase inhibitor, has no detectable sequence similarity with plant and parasite inhibitors, but it is related to a human putative tumor suppressor protein, TIG1. Latexin is expressed in the developing brain, and we find that it plays a role in inflammation, as it is expressed at high levels and is inducible in macrophages in concert with other protease inhibitors and potential protease targets. The crystal structure of mouse latexin, solved at 1.83 A resolution, shows no structural relationship with other carboxypeptidase inhibitors. Furthermore, despite a lack of detectable sequence duplication, the structure incorporates two topologically analogous domains related by pseudo two-fold symmetry. Surprisingly, these domains share a cystatin fold architecture found in proteins that inhibit cysteine proteases, suggesting an evolutionary and possibly functional relationship. The structure of the tumor suppressor protein TIG1 was modeled, revealing its putative membrane binding surface.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wnh ConSurf].
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1WNH is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WNH OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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An inflammatory role for the mammalian carboxypeptidase inhibitor latexin: relationship to cystatins and the tumor suppressor TIG1., Aagaard A, Listwan P, Cowieson N, Huber T, Ravasi T, Wells CA, Flanagan JU, Kellie S, Hume DA, Kobe B, Martin JL, Structure. 2005 Feb;13(2):309-17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15698574 15698574]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Aagaard A]]
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[[Category: Aagaard, A.]]
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[[Category: Cowieson N]]
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[[Category: Cowieson, N.]]
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[[Category: Flanagan JU]]
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[[Category: Flanagan, J U.]]
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[[Category: Huber T]]
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[[Category: Huber, T.]]
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[[Category: Hume DA]]
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[[Category: Hume, D A.]]
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[[Category: Kobe B]]
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[[Category: Kobe, B.]]
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[[Category: Listwan P]]
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[[Category: Listwan, P.]]
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[[Category: Martin JL]]
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[[Category: Martin, J L.]]
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[[Category: Ravasi T]]
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[[Category: Ravasi, T.]]
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[[Category: Wells CA]]
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[[Category: Wells, C A.]]
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[[Category: bi-cystatin fold]]
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[[Category: cis-proline]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:38:38 2008''
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Current revision

Crystal structure of mouse Latexin (tissue carboxypeptidase inhibitor)

PDB ID 1wnh

Drag the structure with the mouse to rotate

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OCA

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