5mu0
From Proteopedia
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==ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)== | ==ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)== | ||
| - | <StructureSection load='5mu0' size='340' side='right' caption='[[5mu0]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='5mu0' size='340' side='right'caption='[[5mu0]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5mu0]] is a 24 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MU0 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIR:CITRULLINE'>CIR</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mu0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mu0 OCA], [https://pdbe.org/5mu0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mu0 RCSB], [https://www.ebi.ac.uk/pdbsum/5mu0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mu0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Defects in Col2a1 are the cause of a phenotype resembling human spondyloepiphyseal dysplasia congenita (sedc). Homozygous sedc mice can be identified at birth by their small size and shortened trunk. Adults have shortened noses, dysplastic vertebrae, femora and tibias, and retinoschisis and hearing loss. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CO2A1_MOUSE CO2A1_MOUSE] Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 5mu0" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 5mu0" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Antibody 3D structures|Antibody 3D structures]] | ||
| + | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Dobritzsch | + | [[Category: Dobritzsch D]] |
| - | [[Category: Ge | + | [[Category: Ge C]] |
| - | [[Category: Holmdahl | + | [[Category: Holmdahl R]] |
| - | + | ||
Current revision
ACC1 Fab fragment in complex with citrullinated C1 epitope of CII (IA03)
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