5l7p

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==In silico-powered specific incorporation of photocaged Dopa at multiple protein sites==
==In silico-powered specific incorporation of photocaged Dopa at multiple protein sites==
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<StructureSection load='5l7p' size='340' side='right' caption='[[5l7p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='5l7p' size='340' side='right'caption='[[5l7p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l7p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L7P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l7p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanocaldococcus_jannaschii_DSM_2661 Methanocaldococcus jannaschii DSM 2661]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L7P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BUU:(2~{S})-2-azanyl-3-[3-[(2-nitrophenyl)methoxy]-4-oxidanyl-phenyl]propanoic+acid'>BUU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=BUU:(2~{S})-2-azanyl-3-[3-[(2-nitrophenyl)methoxy]-4-oxidanyl-phenyl]propanoic+acid'>BUU</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7p OCA], [http://pdbe.org/5l7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l7p RCSB], [http://www.ebi.ac.uk/pdbsum/5l7p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l7p OCA], [https://pdbe.org/5l7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l7p RCSB], [https://www.ebi.ac.uk/pdbsum/5l7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l7p ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SYY_METJA SYY_METJA]] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
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[https://www.uniprot.org/uniprot/SYY_METJA SYY_METJA] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).<ref>PMID:10585437</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l7p" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l7p" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Tyrosine--tRNA ligase]]
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[[Category: Large Structures]]
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[[Category: Baumann, T]]
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[[Category: Methanocaldococcus jannaschii DSM 2661]]
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[[Category: Budisa, N]]
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[[Category: Baumann T]]
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[[Category: Dobbek, H]]
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[[Category: Budisa N]]
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[[Category: Durkin, P]]
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[[Category: Dobbek H]]
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[[Category: Hauf, M]]
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[[Category: Durkin P]]
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[[Category: Martins, B M]]
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[[Category: Hauf M]]
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[[Category: Moeglich, A]]
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[[Category: Martins BM]]
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[[Category: Richter, F]]
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[[Category: Moeglich A]]
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[[Category: Schneider, T]]
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[[Category: Richter F]]
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[[Category: Ligase]]
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[[Category: Schneider T]]
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[[Category: Tyrr]]
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In silico-powered specific incorporation of photocaged Dopa at multiple protein sites

PDB ID 5l7p

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