1woq

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[[Image:1woq.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution==
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|PDB= 1woq |SIZE=350|CAPTION= <scene name='initialview01'>1woq</scene>, resolution 1.80&Aring;
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<StructureSection load='1woq' size='340' side='right'caption='[[1woq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GLC:GLUCOSE'>GLC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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<table><tr><td colspan='2'>[[1woq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_sp._KM Arthrobacter sp. KM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WOQ FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyphosphate--glucose_phosphotransferase Polyphosphate--glucose phosphotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.63 2.7.1.63] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1woq OCA], [https://pdbe.org/1woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1woq RCSB], [https://www.ebi.ac.uk/pdbsum/1woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1woq ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1woq OCA], [http://www.ebi.ac.uk/pdbsum/1woq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1woq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q7WT42_ARTSK Q7WT42_ARTSK]
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== Evolutionary Conservation ==
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'''Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wo/1woq_consurf.spt"</scriptWhenChecked>
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Inorganic polyphosphate (poly(P)) is a biological high energy compound presumed to be an ancient energy carrier preceding ATP. Several poly(P)-dependent kinases that use poly(P) as a phosphoryl donor are known to function in bacteria, but crystal structures of these kinases have not been solved. Here we present the crystal structure of bacterial poly(P)/ATP-glucomannokinase, belonging to Gram-positive bacterial glucokinase, complexed with 1 glucose molecule and 2 phosphate molecules at 1.8 A resolution, being the first among poly(P)-dependent kinases and bacterial glucokinases. The poly(P)/ATP-glucomannokinase structure enabled us to understand the structural relationship of bacterial glucokinase to eucaryotic hexokinase and ADP-glucokinase, which has remained a matter of debate. These comparisons also enabled us to propose putative binding sites for phosphoryl groups for ATP and especially for poly(P) and to obtain insights into the evolution of kinase, particularly from primordial poly(P)-specific to ubiquitous ATP-specific proteins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1WOQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arthrobacter_sp. Arthrobacter sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WOQ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1woq ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of bacterial inorganic polyphosphate/ATP-glucomannokinase. Insights into kinase evolution., Mukai T, Kawai S, Mori S, Mikami B, Murata K, J Biol Chem. 2004 Nov 26;279(48):50591-600. Epub 2004 Sep 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15377666 15377666]
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</StructureSection>
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[[Category: Arthrobacter sp.]]
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[[Category: Arthrobacter sp. KM]]
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[[Category: Polyphosphate--glucose phosphotransferase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Kawai S]]
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[[Category: Kawai, S.]]
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[[Category: Mikami B]]
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[[Category: Mikami, B.]]
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[[Category: Mori S]]
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[[Category: Mori, S.]]
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[[Category: Mukai T]]
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[[Category: Mukai, T.]]
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[[Category: Murata K]]
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[[Category: Murata, K.]]
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[[Category: atp]]
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[[Category: glucomannokinase]]
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[[Category: polyphosphate]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:39:07 2008''
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Current revision

Crystal Structure of Inorganic Polyphosphate/ATP-Glucomannokinase From Arthrobacter sp. strain KM At 1.8 A Resolution

PDB ID 1woq

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