5w0c

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(New page: ==Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex== <StructureSection load='5w0c' size='340' side='right' caption='5w0c, resolution 2.00&Aring;' scene=''> == Structu...)
Current revision (14:03, 4 October 2023) (edit) (undo)
 
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==Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex==
==Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex==
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<StructureSection load='5w0c' size='340' side='right' caption='[[5w0c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='5w0c' size='340' side='right'caption='[[5w0c]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5w0c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W0C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5W0C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5w0c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W0C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9W6:ethyl+{2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate'>9W6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.001&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5w0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w0c OCA], [http://pdbe.org/5w0c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5w0c RCSB], [http://www.ebi.ac.uk/pdbsum/5w0c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5w0c ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9W6:ethyl+{2-[([1,3]thiazolo[4,5-c]pyridine-2-carbonyl)amino]thiophene-3-carbonyl}carbamate'>9W6</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w0c OCA], [https://pdbe.org/5w0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w0c RCSB], [https://www.ebi.ac.uk/pdbsum/5w0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w0c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
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[https://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5w0c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5w0c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hsu, M H]]
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[[Category: Homo sapiens]]
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[[Category: Johnson, E F]]
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[[Category: Large Structures]]
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[[Category: Cyp2c9]]
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[[Category: Hsu M-H]]
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[[Category: Cytochrome p450 2c9]]
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[[Category: Johnson EF]]
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[[Category: Inhibitor complex]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: P450 monooxygenase]]
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Current revision

Cytochrome P450 (CYP) 2C9 TCA007 Inhibitor Complex

PDB ID 5w0c

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