Protein G

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<StructureSection load='1uwx' size='340' side='right' caption='Protein G domain II (grey) complex with mouse Fab heavy chain (red) and light chain (aqua) (PDB code [[1uwx]]).' scene=''>
<StructureSection load='1uwx' size='340' side='right' caption='Protein G domain II (grey) complex with mouse Fab heavy chain (red) and light chain (aqua) (PDB code [[1uwx]]).' scene=''>
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'''Protein G''' (ProG) is a cell surface protein from Streptococcal bacteria which binds Fab and Fc regions of immunoglobulins<ref>PMID:3131664</ref>.
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'''Protein G''' or '''immunoglobulin-binding protein G''' (ProG) is a cell surface protein from Streptococcal bacteria which binds Fab and Fc regions of immunoglobulins<ref>PMID:3131664</ref>.
For ProG immunoglobulin-binding domain see [[Chameleon peptide]].
For ProG immunoglobulin-binding domain see [[Chameleon peptide]].
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{{#tree:id=OrganizedByTopic|openlevels=0|
{{#tree:id=OrganizedByTopic|openlevels=0|
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*Protein G
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*Streptococcus Protein G residues 2-68
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**[[6u8c]] – StProG + antibody – ''Streptococcus''<br />
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*Streptococcus Protein G residues 56-118
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**[[1uwx]] – StProG + Igg1 Fab<br />
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**[[1qkz]] – StProG (mutant) + Igg1 Fab + peptide antigen<br />
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*Streptococcus Protein G residues 189-244
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**[[1em7]] – StProG (mutant) <br />
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*Streptococcus Protein G B1 domain residues 228-282
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**[[1pga]], [[1pgb]], [[2ju6]], [[2rmm]], [[2rpv]], [[1mpe]], [[1q10]], [[2j52]], [[2j53]], [[2k0p]], [[3mp9]], [[1gb1]], [[2gi9]] - StProG <br />
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**[[2gb1]], [[3gb1]], [[5ub0]], [[5ubs]], [[5uce]],[[2n9k]], [[5ucf]], [[2n9l]], [[2plp]], [[6che]], [[1qmt]], [[2lgi]], [[2nmq]], [[2rpv]] - StProG - NMR <br />
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**[[1mvk]], [[1fcl]], [[1fd6]], [[1em7]], [[3v3x]], [[6c9o]], [[6kmc]], [[6nla]], [[6nlb]], [[6nl9]], [[6nl8]], [[6nl7]], [[6nl6]], [[5ofs]], [[6cne]], [[6cpz]], [[4wh4]], [[6l9b]], [[6lji]], [[5bmi]], [[5bmh]], [[6l91]], [[6l9d]], [[5hg2]], [[5hfy]], [[5hi1]] – StProG (mutant) <br />
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**[[1q10]], [[2rmm]], [[2k0p]], [[2ju6]] – StProG (mutant) – NMR<br />
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**[[1mi0]], [[1mhx]] – ProG (mutant) – ''Finegoldia magna''<br />
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*Streptococcus Protein G albumin-binding domain residues 254-299
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**[[1pgx]] – StProG – ''Streptococcus''<br />
 
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**[[1gb1]], [[2gb1]], [[2igg]], [[2igh]] - SgProG immunoglobulin-binding domain – ''Streptomyces griseus'' – NMR<br />
 
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**[[2igg]], [[2igh]] - SgProG immunoglobulin-binding domains II+III – NMR<br />
 
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**[[1pga]], [[1pgb]], [[2on8]], [[3fil]] - StProG immunoglobulin-binding domain <br />
 
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**[[1zxh]], [[2ju6]], [[2rmm]], [[2jsv]], [[2rpv]], [[2kq4]], [[2kwd]] - StProG immunoglobulin-binding domain (mutant) - NMR<br />
 
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**[[2klk]] - StProG immunoglobulin-binding domain - NMR<br />
 
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**[[2onq]] - StProG immunoglobulin-binding domain (mutant) <br />
 
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**[[2plp]] - StProG immunoglobulin-binding domain I - NMR<br />
 
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**[[2igd]] - StProG immunoglobulin-binding domain III<br />
 
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**[[1p7e]], [[1p7f]], [[2lum]] - StProG immunoglobulin-binding domain III - NMR<br />
 
**[[1gjs]], [[1gjt]] - StProG albumin-binding domain - NMR<br />
**[[1gjs]], [[1gjt]] - StProG albumin-binding domain - NMR<br />
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**[[1igd]] - StProG immunoglobulin-binding domain III<br />
 
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**[[3mp3]] - StProG domain B1 <br />
 
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**[[3gb1]] – StProG domain B1 – NMR<br />
 
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**[[1gb4]], [[1fcl]], [[1fd6]], [[1mpe]], [[1q10]], [[2j52]], [[2j53]], [[2k0p]] – StProG domain B1 (mutant) – NMR<br />
 
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**[[1em7]], [[1mvk]], [[3v3x]] – StProG domain B1 (mutant) <br />
 
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**[[2zw0]], [[2zw1]] - ProG B1 domain (mutant) - ''Finegoldia magna''<br />
 
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**[[2gi9]], [[2qmt]] – ProG domain B1 (mutant) – ''Staphylococcus aureus''<br />
 
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*Protein G complex with immunoglobulin
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*Streptococcus Protein G 3rd Igg-binding domain residues 300-357
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**[[3fil]], [[1pgx]], [[2igd]], [[1igd]] - StProG <br />
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**[[3v3x]], [[5bmg]], [[6c9o]], [[6cte]], [[6nl6]], [[6nl7]], [[6nl8]], [[6nl9]], [[6nlb]] – StProG (mutant) <br />
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**[[2plp]], [[1p7f]], [[1p7e]], [[2n7j]], [[2lum]] - StProG - NMR<br />
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**[[2jsv]], [[2kq4]], [[2kwd]], [[1fcl]], [[1fd6]] - StProG (mutant) - NMR<br />
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**[[1igc]] – StProG + Igg1 Fab<br />
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**[[6o41]] – StProG + antibody<br />
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*Streptococcus Protein G domains II+III residues 367-430
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**[[2on8]], [[2igg]] - StProG <br />
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**[[2igh]] – StProG – NMR<br />
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**[[2onq]], [[2on8]] – StProG (mutant) <br />
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**[[1gb4]], [[6njf]] – StProG (mutant) – NMR<br />
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**[[1fcc]] – StProG + Igg1 Fc<br />
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*Streptococcus Protein G residues 443-497
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**[[1p7e]], [[1p7f]], [[2lum]], [[2oed]] - StProG - NMR<br />
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**[[1zxh]] - StProG (mutant) - NMR<br />
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**[[6oc7]] – StProG + antibody<br />
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**[[6wfw]] – StProG + antibody + peptide<br />
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*Protein G
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**[[1gb1]], [[2gb1]], [[2igg]], [[2igh]] - SgProG immunoglobulin-binding domain – Streptomyces griseus – NMR<br />
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**[[2igg]], [[2igh]] - SgProG immunoglobulin-binding domains II+III – NMR<br />
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**[[2gi9]], [[2qmt]] – SaProG domain B1 (mutant) – Staphylococcus aureus<br />
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**[[2klk]] - SaProG immunoglobulin-binding domain - NMR<br />
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**[[1fcc]] – StProG C2 fragment + Igg1 Fc<br />
 
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**[[1uwx]] – StProG domain II + Igg1 Fab<br />
 
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**[[1igc]] – StProG domain III + Igg1 Fab<br />
 
}}
}}
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Protein G domain II (grey) complex with mouse Fab heavy chain (red) and light chain (aqua) (PDB code 1uwx).

Drag the structure with the mouse to rotate

3D Structures of protein G

Updated on 03-February-2022

References

  1. ↑ Erntell M, Myhre EB, Sjobring U, Bjorck L. Streptococcal protein G has affinity for both Fab- and Fc-fragments of human IgG. Mol Immunol. 1988 Feb;25(2):121-6. PMID:3131664

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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