1h8a

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==CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3==
==CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3==
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<StructureSection load='1h8a' size='340' side='right' caption='[[1h8a]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
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<StructureSection load='1h8a' size='340' side='right'caption='[[1h8a]], [[Resolution|resolution]] 2.23&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1h8a]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H8A FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1h8a]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Avian_myeloblastosis_virus Avian myeloblastosis virus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H8A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H8A FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1h88|1h88]], [[1h89|1h89]], [[1hjb|1hjb]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.23&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8a OCA], [http://pdbe.org/1h8a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h8a RCSB], [http://www.ebi.ac.uk/pdbsum/1h8a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8a ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h8a OCA], [https://pdbe.org/1h8a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h8a RCSB], [https://www.ebi.ac.uk/pdbsum/1h8a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h8a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN]] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
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[https://www.uniprot.org/uniprot/CEBPB_HUMAN CEBPB_HUMAN] Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor gamma (PPARG).<ref>PMID:20829347</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8a_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h8/1h8a_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ogata, K]]
 
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[[Category: Tahirov, T H]]
 
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[[Category: Amv]]
 
[[Category: Avian myeloblastosis virus]]
[[Category: Avian myeloblastosis virus]]
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[[Category: Bzip]]
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[[Category: Homo sapiens]]
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[[Category: C-myb]]
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[[Category: Large Structures]]
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[[Category: C/ebp]]
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[[Category: Ogata K]]
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[[Category: Protein-dna complex]]
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[[Category: Tahirov TH]]
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[[Category: Transcription regulation]]
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[[Category: Transcription-dna complex]]
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[[Category: Transcription/dna]]
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[[Category: Transforming protein]]
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[[Category: V-myb]]
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Current revision

CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3

PDB ID 1h8a

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