1h39

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==Structures of human oxidosqualene cyclase inhibitors bound to a homolgous enzyme==
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==Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme==
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<StructureSection load='1h39' size='340' side='right' caption='[[1h39]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='1h39' size='340' side='right'caption='[[1h39]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1h39]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H39 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1H39 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1h39]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1H39 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1H39 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R03:ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE'>R03</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gsz|1gsz]], [[1h35|1h35]], [[1h36|1h36]], [[1h37|1h37]], [[1h3a|1h3a]], [[1h3b|1h3b]], [[1h3c|1h3c]], [[1sqc|1sqc]], [[2sqc|2sqc]], [[3sqc|3sqc]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C8E:(HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE'>C8E</scene>, <scene name='pdbligand=R03:ALLYL-{6-[3-(4-BROMO-PHENYL)-1-METHYL-1H-INDAZOL-6-YL]OXY}HEXYL)-N-METHYLAMINE'>R03</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Squalene--hopene_cyclase Squalene--hopene cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.4.99.17 5.4.99.17] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1h39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h39 OCA], [https://pdbe.org/1h39 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1h39 RCSB], [https://www.ebi.ac.uk/pdbsum/1h39 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1h39 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1h39 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1h39 OCA], [http://pdbe.org/1h39 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1h39 RCSB], [http://www.ebi.ac.uk/pdbsum/1h39 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1h39 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SQHC_ALIAD SQHC_ALIAD] Catalyzes the cyclization of squalene into hopene.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h39_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h3/1h39_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Squalene--hopene cyclase]]
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[[Category: Alicyclobacillus acidocaldarius]]
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[[Category: Aebi, J D]]
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[[Category: Large Structures]]
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[[Category: Dehmlow, H]]
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[[Category: Aebi JD]]
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[[Category: Lenhart, A]]
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[[Category: Dehmlow H]]
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[[Category: Morand, O H]]
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[[Category: Lenhart A]]
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[[Category: Reinert, D J]]
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[[Category: Morand OH]]
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[[Category: Schulz, G E]]
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[[Category: Reinert DJ]]
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[[Category: Weihofen, W A]]
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[[Category: Schulz GE]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Weihofen WA]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Monotopic membrane protein]]
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Current revision

Structures of Human Oxidosqualene Cyclase Inhibitors Bound to an Homologous Enzyme

PDB ID 1h39

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