Response regulator

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Se-Met DNA-binding response regulator D complex with thiocyanate, 1kgs

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References

↑ Smith JG, Latiolais JA, Guanga GP, Citineni S, Silversmith RE, Bourret RB. Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. J Bacteriol. 2003 Nov;185(21):6385-91. PMID:14563873
↑ Ladds JC, Muchova K, Blaskovic D, Lewis RJ, Brannigan JA, Wilkinson AJ, Barak I. The response regulator Spo0A from Bacillus subtilis is efficiently phosphorylated in Escherichia coli. FEMS Microbiol Lett. 2003 Jun 27;223(2):153-7. PMID:12829280
↑ Hecht GB, Newton A. Identification of a novel response regulator required for the swarmer-to-stalked-cell transition in Caulobacter crescentus. J Bacteriol. 1995 Nov;177(21):6223-9. PMID:7592388
↑ Menon S, Wang S. Structure of the Response Regulator PhoP from Mycobacterium tuberculosis Reveals a Dimer through the Receiver Domain. Biochemistry. 2011 Jul 5;50(26):5948-57. Epub 2011 Jun 13. PMID:21634789 doi:10.1021/bi2005575
↑ Eraso JM, Kaplan S. Complex regulatory activities associated with the histidine kinase PrrB in expression of photosynthesis genes in Rhodobacter sphaeroides 2.4.1. J Bacteriol. 1996 Dec;178(24):7037-46. PMID:8955382
↑ Malone JG, Williams R, Christen M, Jenal U, Spiers AJ, Rainey PB. The structure-function relationship of WspR, a Pseudomonas fluorescens response regulator with a GGDEF output domain. Microbiology. 2007 Apr;153(Pt 4):980-94. PMID:17379708 doi:http://dx.doi.org/10.1099/mic.0.2006/002824-0
↑ Allen JF. Redox control of transcription: sensors, response regulators, activators and repressors. FEBS Lett. 1993 Oct 18;332(3):203-7. PMID:8405457

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Response regulator

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3D Structures of response regulator

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-<StructureSection load='1kgs' size='400' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
+<StructureSection load='1kgs' size='350' side='right' scene='' caption='Se-Met DNA-binding response regulator D complex with thiocyanate, [[1kgs]]'>
 '''Response regulators''' (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments.
 Two-component RR is a complex of histidine kinase (sensor protein SP) and RR.  The RR act as phosphorylation-activated switches.  Most RR consist of N terminal which is the signal receiving domain and C terminal which is the DNA-binding domain (DBD).
-*'''RR CheY''' is a chemotaxis  response regulator in bacteria<ref>PMID:14563873</ref>. <br />
+*'''RR CheY''' is a chemotaxis  response regulator in bacteria see [[Chemotaxis protein]].<ref>PMID:14563873</ref>. <br />
 *'''RR Spo0''' is the sporulation response regulator<ref>PMID:12829280</ref>. <br />
 *'''RR PleD''' is required in loss of motility<ref>PMID:7592388</ref>. For details see [[PleD activation]], [[PleD allosteric product inhibition]], [[PleD catalysis]] and [[Response regulator PLED in complex with C-di-GMP]]<br />
@@ Line 11: / Line 10: @@
 *'''RR WspR''' couples the chemosensory Wsp pathway to the overproduction of acetylated cellulase <ref>PMID:17379708</ref>. For details see [[WspR]].<br />
 *'''Redox RR''' is DNA-sequence specific.  It controls transcription as a result of its phosphorylation by a redox sensor<ref>PMID:8405457</ref>. <br />
-</StructureSection>
-== 3D Structures of response regulator ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+For '''iron response regulator Irr''' see [[Irr]].
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*Nitrate/nitrite response regulator
+== 3D Structures of response regulator ==
+[[Response regulator 3D structure]]
-**[[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ >
+</StructureSection>
-**[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA
-*Sporulation response regulator
-**[[1srr]], [[2jvi]], [[2jvj]], [[2jvk]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ >
-**[[1nat]] - BsSpo0F<br/ >
-**[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ >
-**[[1ixm]] - BsSpo0B<br/ >
-**[[1fc3]] – GsSpo0A trans-activation domain – ''Geobacillus stearothermophilus''<br />
-**[[1dz3]], [[1qmp]] - GsSpo0A reciever domain
-*DNA-binding response regulator
-**[[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ >
-**[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ >
-**[[1p2f]] – TmDrrB<br/ >
-**[[3nns]] - TmDrrB receiver domain + BeF3<BR/ >
-**[[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ >
-**[[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ >
-**[[2hwv]] – EfVicR C terminal – ''Enterococcus faecalis''<br/ >
-**[[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ >
-**[[3cnb]], [[3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ >
-**[[2rnj]] – SaVraR DBD – ''Staphylococcus aureus'' – NMR<br/ >
-**[[2zxj]] - SaWalR DBD<br/ >
-**[[4gvp]] – SaVraR<br />
-**[[4if4]] – SaVraR + Mg + BeF3<br />
-**[[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ >
-**[[3q9v]] - DrRR C terminal<br />
-**[[3rjp]] - RR DBD – ''Streptococcus pyogenes''<br />
-**[[2a9r]] – SpRR N terminal + phosphate + Mg
-*Cyanobacterial phytochrome response regulator
-**[[1i3c]] – SyRcp1 – ''Synechocystis''<br/ >
-**[[1jlk]] – SyRcp1 + Mn<br/ >
-**[[1k66]] – ToRcpB – ''Tolypothrix''<br/ >
-**[[1k68]] – ToRcpB
-*Phosphatase synthesis response regulator
-**[[1mvo]] – BsPhoP receiver domain<br/ >
-**[[2jb9]], [[2jba]] – EcPhoB (mutant) <br/ >
-**[[2pmu]] – MtPhoP DBD
-*Polar differentiation response regulator
-**[[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ >
-**[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation
-*Photosynthetic apparatus response regulator
-**[[1umq]] – PrrA DBD – ''Rhodobacter sphaeroides'' – NMR<br/ >
-**[[1ys6]] – MtPrrA <br/ >
-**[[1ys7]] – MtPrrA + Mg
-*Redox response regulator
-**[[1xhe]] – EcArcA receiver domain <br/ >
-**[[1xhf]] – EcArcA receiver domain + BeF3<BR/ >
-**[[4ynr]] - MtDevs GAF domain + CO<br />
-**[[4yof]] - MtDevs GAF domain + NO<br />
-**[[2y79]] – MtDevs GAF domain (mutant)<br />
-**[[3zxo]] - MtDevs ATP-binding domain (mutant)<br />
-*Social motility response regulator
-**[[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ >
-**[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant)
-*Stalked-cell differentiation response regulator
-**[[2v0n]] – CvPleD + GMP + GTP<br/ >
-**[[2wb4]], [[1w25]] - CvPleD + GMP
-*Hypoxia response regulator
-**[[3c3w]], [[1zlj]] – MtDosR<br/ >
-**[[3c57]] – MtDosR C terminal<br />
-**[[1zlk]] – MtDosR C terminal + DNA<br />
-**[[3zxo]] – MtDost ATP-binding domain<br />
-*Transcriptional response regulator
-**[[2zwm]] – BsYycF receiver domain<br/ >
-**[[5iuj]], [[5iuk]], [[5iul]], [[5iun]] - BsDesR + DesK<br />
-**[[3ulq]] – BsComA DBD + RR aspartate phosphatase<br />
-**[[2pkx]] – EcPhoP regulatory domain<br />
-**[[5ed4]] - MtPhoP + DNA<br />
-**[[3nhz]] – MtMtra N terminal<br />
-**[[5fmn]] - SyInrS<br />
-**[[5lwk]] - LpMaeR + BeF3 - ''Lactobacillus paracasei''<br />
-**[[5lwl]] - LpMaeR (mutant)<br />
-**[[4g9y]] - ScPcaV - ''Streptomyces coelicolor''<br />
-**[[4fht]] - ScPcaV + hydroxybenzoic acid<br />
-**[[4u88]] - SaSaeR DBD<br />
-**[[4ixa]] - SaeR DBD - ''Staphylococcus epidermidis''<br />
-**[[4so5]] - BasR + DNA - ''Klebsiella pneumoniae''<br />
-*Stress response regulator
-**[[3n0r]] – CVPhyR<br />
-**[[5i4c]] - EcRcsB receiver domain<br />
-**[[3cra]], [[3crc]] - EcMazG<br />
-**[[2v42]], [[2v43]] - EcRseB<br />
-*Chemotaxis response regulator see [[Chemotaxix protein]]
-*Two-component response regulator
-**[[2lpm]] – SmRR <br />
-**[[2m98]] – RR – ''Sinorhizobium meliloti''<br />
-**[[4q7e]] – RR receiver domain – ''Leptospira biflexa''<br />
-**[[2qr3]] – RR N terminal – ''Bacteroides fragilis''<br />
-**[[2qzj]] – RR – ''Clostridium difficile''<br />
-**[[3cz5]] – RR – ''Aurantimonas''<br />
-**[[2qvg]] - RR - ''Legionella pneumophila''<br />
-**[[3ilh]] - RR - ''Cytophaga hutchinsonii''<br />
-**[[5brj]] - RR - ''Agrobacterium tumefaciens''<br />
-**[[5uic]] - QseB - ''Francisella tularensis''<br />
-**[[3lsg]] - RR C-terminal - ''Fusobacterium nucleatum''<br />
-**[[3p01]] - RR - Nostoc<br />
-*response regulator receiver domain protein
-**[[4wsz]] – EfRR<br />
-**[[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ >
-**[[3heb]] - RR – ''Rhodospirillum rubrum''<br/ >
-**[[3lte]] – RR – ''Bermanella marisrubri''<br/ >
-**[[3jte]], [[3lua]] – RR – ''Clostridium thermocellum''<br />
-**[[4wt0]] – EfRR DNA-binding domain (mutant)<br />
-**[[4wu4]], [[4wuh]], [[4wul]] – EfRR DNA-binding domain + DNA<br />
-**[[4xlt]] – RR – ''Dyadobacter fermentans''<br />
-*Unspecified response regulator
-**[[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ >
-**[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ >
-**[[2qvg]] – RR – ''Legionella pneumophila''<br/ >
-**[[3gl9]], [[2qxy]], [[4ja2]] - TmRR<br/ >
-**[[4hye]] – SpRR<br />
-**[[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ >
-**[[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ >
-**[[3hdv]] – RR – ''Pseudomonas putida''<br/ >
-**[[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ >
-**[[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ >
-**[[3i5b]] – PaWspR GGDEF domain<br/ >
-**[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ >
-**[[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ >
-**[[3p3q]] – McMmoQ (mutant) <br/ >
-**[[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ >
-**[[3nhm]] – MxRR<br/ >
-**[[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ >
-**[[3qyy]] – XcRR GGDEF domain + GMP<br/ >
-**[[3p01]] – RR residues 134-315 – ''Nostoc''<br/ >
-**[[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ >
-**[[3kto]] – RR - ''Pseudoalteromonas atlantica''<br />
-**[[3t0y]] – CvRR anti-anti-σ domain + anti-σ factor NEPR<br />
-**[[2oqr]] – MtRR Regx3 <br />
-**[[3sy8]] – PaRR Rocr <br />
-**[[4ixa]] – RR Saer DNA-binding domain – ''Staphylococcus epidermidis''<br />
-**[[4ml3]], [[4mld]] – SpRR Rec domain (mutant)<br />
-**[[4cbv]] – SpRR (mutant)<br />
-**[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<br />
-**[[2pln]] – HP1043 – ''Helicobacter pylori''<br />
-**[[3kht]] – RR – ''Hahella chejuensis''
-*Response regulator complex with histidine kinase
-**[[3dge]], [[3dgf]] – TmRR + sensor protein<br/ >
-**[[3a0r]] – TmTrrA (mutant) + sensor protein<br />
-**[[4jas]], [[4jav]] – TmRR (mutant) + histidine kinase<br />
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]