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5uul

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==Human Bfl-1 in complex with PUMA BH3==
==Human Bfl-1 in complex with PUMA BH3==
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<StructureSection load='5uul' size='340' side='right' caption='[[5uul]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
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<StructureSection load='5uul' size='340' side='right'caption='[[5uul]], [[Resolution|resolution]] 1.33&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5uul]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UUL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5uul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5UUL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.33&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5uuk|5uuk]], [[5uum|5uum]], [[5uup|5uup]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5uul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uul OCA], [https://pdbe.org/5uul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5uul RCSB], [https://www.ebi.ac.uk/pdbsum/5uul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5uul ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uul OCA], [http://pdbe.org/5uul PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uul RCSB], [http://www.ebi.ac.uk/pdbsum/5uul PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uul ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN]] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity). [[http://www.uniprot.org/uniprot/BBC3_HUMAN BBC3_HUMAN]] Essential mediator of p53/TP53-dependent and p53/TP53-independent apoptosis. Functions by promoting partial unfolding of BCL2L1 and dissociation of BCL2L1 from p53/TP53. Regulates ER stress-induced neuronal apoptosis.<ref>PMID:11463391</ref> <ref>PMID:23340338</ref>
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[https://www.uniprot.org/uniprot/B2LA1_HUMAN B2LA1_HUMAN] Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5uul" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5uul" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[B-cell lymphoma proteins 3D structures|B-cell lymphoma proteins 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Grant, R A]]
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[[Category: Homo sapiens]]
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[[Category: Jenson, J M]]
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[[Category: Large Structures]]
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[[Category: Keating, A E]]
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[[Category: Grant RA]]
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[[Category: Apoptosis]]
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[[Category: Jenson JM]]
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[[Category: Apoptosis regulatory protein]]
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[[Category: Keating AE]]
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[[Category: Bcl2 related protein a1]]
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[[Category: Bcl2a1]]
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[[Category: Protein binding]]
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[[Category: Protein structure]]
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[[Category: Proto-oncogene]]
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Current revision

Human Bfl-1 in complex with PUMA BH3

PDB ID 5uul

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