1wy2

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[[Image:1wy2.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of the Prolidase from Pyrococcus horikoshii OT3==
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|PDB= 1wy2 |SIZE=350|CAPTION= <scene name='initialview01'>1wy2</scene>, resolution 1.70&Aring;
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<StructureSection load='1wy2' size='340' side='right'caption='[[1wy2]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1wy2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_horikoshii_OT3 Pyrococcus horikoshii OT3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WY2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WY2 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Xaa-Pro_dipeptidase Xaa-Pro dipeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.13.9 3.4.13.9] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wy2 OCA], [https://pdbe.org/1wy2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wy2 RCSB], [https://www.ebi.ac.uk/pdbsum/1wy2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wy2 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wy2 TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1wy2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wy2 OCA], [http://www.ebi.ac.uk/pdbsum/1wy2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1wy2 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PEPQ_PYRHO PEPQ_PYRHO] Splits dipeptides with a prolyl in the C-terminal position and a nonpolar amino acid at the N-terminal position (By similarity).
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== Evolutionary Conservation ==
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'''Crystal Structure of the Prolidase from Pyrococcus horikoshii OT3'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wy/1wy2_consurf.spt"</scriptWhenChecked>
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1WY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_horikoshii Pyrococcus horikoshii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WY2 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Pyrococcus horikoshii]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Xaa-Pro dipeptidase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wy2 ConSurf].
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[[Category: Kunishima, N.]]
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<div style="clear:both"></div>
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[[Category: Mizutani, H.]]
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__TOC__
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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</StructureSection>
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[[Category: prolidase]]
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[[Category: Large Structures]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: Pyrococcus horikoshii OT3]]
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[[Category: rsgi]]
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[[Category: Kunishima N]]
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[[Category: structural genomic]]
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[[Category: Mizutani H]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:42:30 2008''
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Current revision

Crystal Structure of the Prolidase from Pyrococcus horikoshii OT3

PDB ID 1wy2

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