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4zx8

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==X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b==
==X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b==
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<StructureSection load='4zx8' size='340' side='right' caption='[[4zx8]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4zx8' size='340' side='right'caption='[[4zx8]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4zx8]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ZX8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4zx8]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_FcB1/Columbia Plasmodium falciparum FcB1/Columbia]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZX8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=4TY:TERT-BUTYL+[(1R)-1-(4-BROMOPHENYL)-2-(HYDROXYAMINO)-2-OXOETHYL]CARBAMATE'>4TY</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4zx9|4zx9]], [[4zy0|4zy0]], [[4zy1|4zy1]], [[4zy2|4zy2]], [[4zyq|4zyq]], [[3kqz|3kqz]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=4TY:TERT-BUTYL+[(1R)-1-(4-BROMOPHENYL)-2-(HYDROXYAMINO)-2-OXOETHYL]CARBAMATE'>4TY</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Leucyl_aminopeptidase Leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.1 3.4.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx8 OCA], [https://pdbe.org/4zx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4zx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4zx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zx8 OCA], [http://pdbe.org/4zx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4zx8 RCSB], [http://www.ebi.ac.uk/pdbsum/4zx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4zx8 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A024V0B1_PLAFA A0A024V0B1_PLAFA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Leucyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Drinkwater, N]]
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[[Category: Plasmodium falciparum FcB1/Columbia]]
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[[Category: McGowan, S]]
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[[Category: Drinkwater N]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: McGowan S]]
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[[Category: Hydroxamic acid]]
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[[Category: Inhibitor]]
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[[Category: M17 leucyl-aminopeptidase]]
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[[Category: Protease]]
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Current revision

X-ray crystal structure of PfA-M17 in complex with hydroxamic acid-based inhibitor 9b

PDB ID 4zx8

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