1hv2

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==SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE==
==SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE==
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<StructureSection load='1hv2' size='340' side='right' caption='[[1hv2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1hv2' size='340' side='right'caption='[[1hv2]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HV2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1hv2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HV2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HV2 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [http://pdbe.org/1hv2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hv2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hv2 OCA], [https://pdbe.org/1hv2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hv2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hv2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hv2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST]] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref> [[http://www.uniprot.org/uniprot/VHL_MOUSE VHL_MOUSE]] Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
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[https://www.uniprot.org/uniprot/ELOC_YEAST ELOC_YEAST] Prevents degradation of interacting proteins like PCL6 by the proteasome.<ref>PMID:11864988</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hv2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hv/1hv2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1hv2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1hv2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Elongation factor 3D structures|Elongation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Large Structures]]
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[[Category: Botuyan, M V]]
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[[Category: Mus musculus]]
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[[Category: Case, D A]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Chazin, W J]]
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[[Category: Arrowsmith CH]]
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[[Category: Edwards, A M]]
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[[Category: Botuyan MV]]
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[[Category: Koth, C M]]
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[[Category: Case DA]]
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[[Category: Mer, G]]
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[[Category: Chazin WJ]]
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[[Category: Yi, G S]]
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[[Category: Edwards AM]]
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[[Category: Protein-peptide complex]]
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[[Category: Koth CM]]
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[[Category: Signaling protein]]
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[[Category: Mer G]]
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[[Category: Yi G-S]]

Current revision

SOLUTION STRUCTURE OF YEAST ELONGIN C IN COMPLEX WITH A VON HIPPEL-LINDAU PEPTIDE

PDB ID 1hv2

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