1hn2

From Proteopedia

(Difference between revisions)

Current revision

CRYSTAL STRUCTURE OF BOVINE OBP COMPLEXED WITH AMINOANTHRACENE

Structural highlights

1hn2 is a 2 chain structure with sequence from Bos taurus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

OBP_BOVIN This protein binds a wide variety of chemical odorants.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Bovine odorant-binding protein (bOBP) is a dimeric lipocalin present in large amounts in the respiratory and olfactory nasal mucosa. The structure of bOBP refined at 2.0-A resolution revealed an elongated volume of electron density inside each buried cavity, indicating the presence of one (or several) naturally occurring copurified ligand(s) (Tegoni et al. (1996) Nat. Struct. Biol. 3, 863-867; Bianchet et al. (1996) Nat. Struct. Biol. 3, 934-939). In the present work, by combining mass spectrometry, x-ray crystallography (1.8-A resolution), and fluorescence, it has been unambiguously established that natural bOBP contains the racemic form of 1-octen-3-ol. This volatile substance is a typical component of bovine breath and in general of odorous body emanations of humans and animals. The compound 1-octen-3-ol is also an extremely potent olfactory attractant for many insect species, including some parasite vectors like Anopheles (Plasmodium) or Glossina (Trypanosoma). For the first time, a function can be assigned to an OBP, with a possible role of bOBP in the ecological relationships between bovine and insect species.

The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein.,Ramoni R, Vincent F, Grolli S, Conti V, Malosse C, Boyer FD, Nagnan-Le Meillour P, Spinelli S, Cambillau C, Tegoni M J Biol Chem. 2001 Mar 9;276(10):7150-5. Epub 2000 Dec 12. PMID:11114310^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ramoni R, Vincent F, Grolli S, Conti V, Malosse C, Boyer FD, Nagnan-Le Meillour P, Spinelli S, Cambillau C, Tegoni M. The insect attractant 1-octen-3-ol is the natural ligand of bovine odorant-binding protein. J Biol Chem. 2001 Mar 9;276(10):7150-5. Epub 2000 Dec 12. PMID:11114310 doi:http://dx.doi.org/10.1074/jbc.M010368200

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1hn2"

@@ Line 1: / Line 1: @@
 ==CRYSTAL STRUCTURE OF BOVINE OBP COMPLEXED WITH AMINOANTHRACENE==
-<StructureSection load='1hn2' size='340' side='right' caption='[[1hn2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+<StructureSection load='1hn2' size='340' side='right'caption='[[1hn2]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1hn2]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HN2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1HN2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1hn2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HN2 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3OL:(3R)-OCT-1-EN-3-OL'>3OL</scene>, <scene name='pdbligand=ANC:ANTHRACEN-1-YLAMINE'>ANC</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1obp|1obp]], [[1g85|1g85]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OL:(3R)-OCT-1-EN-3-OL'>3OL</scene>, <scene name='pdbligand=ANC:ANTHRACEN-1-YLAMINE'>ANC</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1hn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hn2 OCA], [http://pdbe.org/1hn2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1hn2 RCSB], [http://www.ebi.ac.uk/pdbsum/1hn2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1hn2 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hn2 OCA], [https://pdbe.org/1hn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hn2 RCSB], [https://www.ebi.ac.uk/pdbsum/1hn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hn2 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/OBP_BOVIN OBP_BOVIN]] This protein binds a wide variety of chemical odorants.
+[https://www.uniprot.org/uniprot/OBP_BOVIN OBP_BOVIN] This protein binds a wide variety of chemical odorants.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hn2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hn2_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 31: / Line 31: @@
 ==See Also==
-*[[Odorant binding protein|Odorant binding protein]]
 *[[Odorant binding protein 3D structures|Odorant binding protein 3D structures]]
 == References ==
@@ Line 38: / Line 37: @@
 </StructureSection>
 [[Category: Bos taurus]]
-[[Category: Cambillau, C]]
+[[Category: Large Structures]]
-[[Category: Spinelli, S]]
+[[Category: Cambillau C]]
-[[Category: Tegoni, M]]
+[[Category: Spinelli S]]
-[[Category: Vincent, F]]
+[[Category: Tegoni M]]
-[[Category: Aminoanthracene]]
+[[Category: Vincent F]]
-[[Category: Odorant-binding protein]]
-[[Category: Olfaction]]
-[[Category: Protein binding]]

1hn2

From Proteopedia

Current revision

CRYSTAL STRUCTURE OF BOVINE OBP COMPLEXED WITH AMINOANTHRACENE

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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