1x48

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[[Image:1x48.gif|left|200px]]
 
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{{Structure
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==Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase==
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|PDB= 1x48 |SIZE=350|CAPTION= <scene name='initialview01'>1x48</scene>
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<StructureSection load='1x48' size='340' side='right'caption='[[1x48]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1x48]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X48 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X48 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= Prkr, Eif2ak2, Pkr, Tik ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x48 OCA], [https://pdbe.org/1x48 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x48 RCSB], [https://www.ebi.ac.uk/pdbsum/1x48 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x48 ProSAT], [https://www.topsan.org/Proteins/RSGI/1x48 TOPSAN]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x48 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x48 OCA], [http://www.ebi.ac.uk/pdbsum/1x48 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x48 RCSB]</span>
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[https://www.uniprot.org/uniprot/E2AK2_MOUSE E2AK2_MOUSE] Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection. In addition to serine/threonine-protein kinase activity, also has tyrosine-protein kinase activity: phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers CDK1 polyubiquitination and subsequent proteolysis, thus leading to G2 arrest (By similarity).
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x48_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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1X48 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X48 OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x48 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: He F]]
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[[Category: He, F.]]
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[[Category: Inoue M]]
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[[Category: Inoue, M.]]
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[[Category: Kigawa T]]
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[[Category: Kigawa, T.]]
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[[Category: Muto Y]]
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[[Category: Muto, Y.]]
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[[Category: Shirouzu M]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Tarada T]]
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[[Category: Shirouzu, M.]]
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[[Category: Yokoyama S]]
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[[Category: Tarada, T.]]
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[[Category: Yokoyama, S.]]
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[[Category: dsrm domain]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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[[Category: structure genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:44:36 2008''
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Current revision

Solution structure of the second DSRM domain in Interferon-induced, double-stranded RNA-activated protein kinase

PDB ID 1x48

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