1x4i

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[[Image:1x4i.gif|left|200px]]
 
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{{Structure
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==Solution structure of PHD domain in inhibitor of growth protein 3 (ING3)==
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|PDB= 1x4i |SIZE=350|CAPTION= <scene name='initialview01'>1x4i</scene>
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<StructureSection load='1x4i' size='340' side='right'caption='[[1x4i]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1x4i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X4I FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= SCRIB; CRIB1; KIAA0147; LAP4; SCRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4i OCA], [https://pdbe.org/1x4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x4i RCSB], [https://www.ebi.ac.uk/pdbsum/1x4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x4i ProSAT], [https://www.topsan.org/Proteins/RSGI/1x4i TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1x4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x4i OCA], [http://www.ebi.ac.uk/pdbsum/1x4i PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1x4i RCSB]</span>
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== Disease ==
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}}
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[https://www.uniprot.org/uniprot/ING3_HUMAN ING3_HUMAN] Defects in ING3 may be a cause of head and neck squamous cell carcinomas (HNSCC) [MIM:[https://omim.org/entry/275355 275355]; also known as squamous cell carcinoma of the head and neck.<ref>PMID:12080476</ref>
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== Function ==
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'''Solution structure of PHD domain in inhibitor of growth protein 3 (ING3)'''
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[https://www.uniprot.org/uniprot/ING3_HUMAN ING3_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.<ref>PMID:12545155</ref> <ref>PMID:14966270</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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==About this Structure==
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Check<jmol>
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1X4I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X4I OCA].
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x4/1x4i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x4i ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: He, F.]]
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[[Category: He F]]
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[[Category: Inoue, M.]]
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[[Category: Inoue M]]
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[[Category: Kigawa, T.]]
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[[Category: Kigawa T]]
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[[Category: Muto, Y.]]
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[[Category: Muto Y]]
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[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
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[[Category: Shirouzu M]]
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[[Category: Shirouzu, M.]]
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[[Category: Terada T]]
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[[Category: Terada, T.]]
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[[Category: Yokoyama S]]
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[[Category: Yokoyama, S.]]
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[[Category: national project on protein structural and functional analyse]]
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[[Category: nmr]]
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[[Category: nppsfa]]
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[[Category: phd domain]]
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[[Category: riken structural genomics/proteomics initiative]]
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[[Category: rsgi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:44:39 2008''
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Current revision

Solution structure of PHD domain in inhibitor of growth protein 3 (ING3)

PDB ID 1x4i

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