5o97

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m (Protected "5o97" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5o97 is ON HOLD
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==Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106==
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<StructureSection load='5o97' size='340' side='right'caption='[[5o97]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5o97]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5O97 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9OE:(5~{Z})-4-azanyl-5-[(3-methoxy-4-oxidanyl-phenyl)methylidene]-1,3-thiazol-2-one'>9OE</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5o97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o97 OCA], [https://pdbe.org/5o97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5o97 RCSB], [https://www.ebi.ac.uk/pdbsum/5o97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5o97 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
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Authors: Zhu, J., Marchand, J.R., Caflisch, A.
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==See Also==
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*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
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Description: Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Caflisch, A]]
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__TOC__
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[[Category: Marchand, J.R]]
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</StructureSection>
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[[Category: Zhu, J]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Caflisch A]]
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[[Category: Marchand JR]]
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[[Category: Zhu J]]

Current revision

Crystal structure of human BRD4(1) bromodomain in complex with JRMBR4106

PDB ID 5o97

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