5oga
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of minimal i-motif domain== | |
| + | <StructureSection load='5oga' size='340' side='right'caption='[[5oga]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5oga]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OGA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DNR:2-DEOXY-N3-PROTONATED+CYTIDINE-5-MONOPHOSPHATE'>DNR</scene>, <scene name='pdbligand=THM:THYMIDINE'>THM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oga OCA], [https://pdbe.org/5oga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oga RCSB], [https://www.ebi.ac.uk/pdbsum/5oga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oga ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C(+) base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C(+) base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes. | ||
| - | + | Prevalent Sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH.,Mir B, Serrano I, Buitrago D, Orozco M, Escaja N, Gonzalez C J Am Chem Soc. 2017 Oct 11;139(40):13985-13988. doi: 10.1021/jacs.7b07383. Epub, 2017 Sep 27. PMID:28933543<ref>PMID:28933543</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5oga" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Buitrago D]] | ||
| + | [[Category: Escaja N]] | ||
| + | [[Category: Gonzalez C]] | ||
| + | [[Category: Mir B]] | ||
| + | [[Category: Orozco M]] | ||
| + | [[Category: Serrano I]] | ||
Current revision
Structure of minimal i-motif domain
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