5owe
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1010== | |
| + | <StructureSection load='5owe' size='340' side='right'caption='[[5owe]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5owe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OWE FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B0E:1,3-bis(oxidanyl)benzo[c]chromen-6-one'>B0E</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5owe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5owe OCA], [https://pdbe.org/5owe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5owe RCSB], [https://www.ebi.ac.uk/pdbsum/5owe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5owe ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Peregrin|Peregrin]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Caflisch | + | </StructureSection> |
| - | [[Category: Zhu | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Caflisch A]] | ||
| + | [[Category: Spiliotopoulos D]] | ||
| + | [[Category: Zhu J]] | ||
Current revision
Crystal structure of the human BRPF1 bromodomain in complex with DSPBP1010
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