1xe7

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[[Image:1xe7.gif|left|200px]]
 
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{{Structure
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==Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold==
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|PDB= 1xe7 |SIZE=350|CAPTION= <scene name='initialview01'>1xe7</scene>, resolution 1.75&Aring;
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<StructureSection load='1xe7' size='340' side='right'caption='[[1xe7]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene>
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<table><tr><td colspan='2'>[[1xe7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XE7 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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|GENE= YML079w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GUN:GUANINE'>GUN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe7 OCA], [https://pdbe.org/1xe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xe7 RCSB], [https://www.ebi.ac.uk/pdbsum/1xe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xe7 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1xe8|1XE8]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xe7 OCA], [http://www.ebi.ac.uk/pdbsum/1xe7 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xe7 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/YMH9_YEAST YMH9_YEAST]
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== Evolutionary Conservation ==
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'''Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xe/1xe7_consurf.spt"</scriptWhenChecked>
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We determined the three-dimensional crystal structure of the protein YML079wp, encoded by a hypothetical open reading frame from Saccharomyces cerevisiae to a resolution of 1.75 A. The protein has no close homologs and its molecular and cellular functions are unknown. The structure of the protein is a jelly-roll fold consisting of ten beta-strands organized in two parallel packed beta-sheets. The protein has strong structural resemblance to the plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) but also to some plant and bacterial enzymes (epimerase, germin). The protein forms homodimers in the crystal, confirming measurements of its molecular mass in solution. Two monomers have their beta-sheet packed together to form the dimer. The presence of a hydrophobic ligand in a well conserved pocket inside the barrel and local sequence similarity with bacterial epimerases may suggest a biochemical function for this protein.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XE7 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XE7 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xe7 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly-roll fold., Zhou CZ, Meyer P, Quevillon-Cheruel S, De La Sierra-Gallay IL, Collinet B, Graille M, Blondeau K, Francois JM, Leulliot N, Sorel I, Poupon A, Janin J, Van Tilbeurgh H, Protein Sci. 2005 Jan;14(1):209-15. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608122 15608122]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Collinet B]]
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[[Category: Collinet, B.]]
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[[Category: Graille M]]
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[[Category: Graille, M.]]
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[[Category: Janin J]]
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[[Category: Janin, J.]]
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[[Category: Leulliot N]]
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[[Category: Leulliot, N.]]
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[[Category: Li de La Sierra-Gallay I]]
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[[Category: Meyer, P.]]
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[[Category: Meyer P]]
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[[Category: Quevillon-Cheruel, S.]]
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[[Category: Quevillon-Cheruel S]]
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[[Category: Sierra-Gallay, I Li de La.]]
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[[Category: Sorel I]]
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[[Category: Sorel, I.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Zhou C-Z]]
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[[Category: Zhou, C Z.]]
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[[Category: cupin superfamily]]
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[[Category: jelly roll motif]]
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[[Category: s. cerevisiae]]
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[[Category: structural genomic]]
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[[Category: yml079wp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:22 2008''
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Current revision

Crystal structure of the YML079w protein from Saccharomyces cerevisiae reveals a new sequence family of the jelly roll fold

PDB ID 1xe7

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