1xfi

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[[Image:1xfi.gif|left|200px]]
 
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{{Structure
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==X-ray structure of gene product from Arabidopsis thaliana At2g17340==
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|PDB= 1xfi |SIZE=350|CAPTION= <scene name='initialview01'>1xfi</scene>, resolution 1.70&Aring;
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<StructureSection load='1xfi' size='340' side='right'caption='[[1xfi]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Mg+Binding+Site+For+Residue+A+400'>AC1</scene> and <scene name='pdbsite=AC2:Mg+Binding+Site+For+Residue+A+401'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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<table><tr><td colspan='2'>[[1xfi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XFI FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE= At2g17340 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 Arabidopsis thaliana])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1578 COG1578]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfi OCA], [https://pdbe.org/1xfi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xfi RCSB], [https://www.ebi.ac.uk/pdbsum/1xfi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xfi ProSAT], [https://www.topsan.org/Proteins/CESG/1xfi TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xfi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xfi OCA], [http://www.ebi.ac.uk/pdbsum/1xfi PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xfi RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/D89S2_ARATH D89S2_ARATH] Metal-dependent phosphatase with probable damage-control functions (PubMed:27322068). Shows phosphatase activity against several substrates, including sugar phosphates and p-nitrophenyl phosphate(pNPP) (PubMed:27322068). Prefers sugar phosphate substrates, including the extremely potent glycating agents ribose-5-phosphate and erythrose-4-phosphate (PubMed:27322068).<ref>PMID:27322068</ref>
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== Evolutionary Conservation ==
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'''X-ray structure of gene product from Arabidopsis thaliana At2g17340'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xf/1xfi_consurf.spt"</scriptWhenChecked>
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The crystal structure of the At2g17340 protein from A. thaliana was determined by the multiple-wavelength anomalous diffraction method and was refined to an R factor of 16.9% (Rfree = 22.1%) at 1.7 A resolution. At2g17340 is a member of the Pfam01937.11 protein family and its structure provides the first insight into the structural organization of this family. A number of fully and highly conserved residues defined by multiple sequence alignment of members of the Pfam01937.11 family were mapped onto the structure of At2g17340. The fully conserved residues are involved in the coordination of a metal ion and in the stabilization of loops surrounding the metal site. Several additional highly conserved residues also map into the vicinity of the metal-binding site, while others are clearly involved in stabilizing the hydrophobic core of the protein. The structure of At2g17340 represents a new fold in protein conformational space.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XFI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XFI OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xfi ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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The structure at 1.7 A resolution of the protein product of the At2g17340 gene from Arabidopsis thaliana., Bitto E, Bingman CA, Allard ST, Wesenberg GE, Phillips GN Jr, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Jul 1;61(Pt, 7):630-5. Epub 2005 Jun 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16511115 16511115]
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<references/>
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__TOC__
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</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Arabidopsis thaliana]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Allard, S T.M.]]
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[[Category: Allard STM]]
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[[Category: Bingman, C A.]]
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[[Category: Bingman CA]]
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[[Category: Bitto, E.]]
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[[Category: Bitto E]]
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[[Category: CESG, Center for Eukaryotic Structural Genomics.]]
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[[Category: Phillips Jr GN]]
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[[Category: Jr., G N.Phillips.]]
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[[Category: Smith DW]]
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[[Category: Smith, D W.]]
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[[Category: Wesenberg GE]]
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[[Category: Wesenberg, G E.]]
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[[Category: at2g17340]]
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[[Category: center for eukaryotic structural genomic]]
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[[Category: cesg]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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[[Category: unknown function]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:48:54 2008''
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Current revision

X-ray structure of gene product from Arabidopsis thaliana At2g17340

PDB ID 1xfi

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OCA

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