5w3g

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m (Protected "5w3g" [edit=sysop:move=sysop])
Current revision (10:28, 14 June 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5w3g is ON HOLD until Paper Publication
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==Solution Structure of ETS Transcription Factor PU.1==
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<StructureSection load='5w3g' size='340' side='right'caption='[[5w3g]]' scene=''>
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Authors: Lau, D.K.W., Okon, M., McIntosh, L.P.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5w3g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5W3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5W3G FirstGlance]. <br>
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Description: Solution Structure of ETS Transcription Factor PU.1
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5w3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5w3g OCA], [https://pdbe.org/5w3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5w3g RCSB], [https://www.ebi.ac.uk/pdbsum/5w3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5w3g ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Lau, D.K.W]]
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== Disease ==
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[[Category: Okon, M]]
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[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Note=Involved in murine acute Friend erythroleukemia. It is a target region for SFFV proviral insertion.
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[[Category: Mcintosh, L.P]]
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== Function ==
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[https://www.uniprot.org/uniprot/SPI1_MOUSE SPI1_MOUSE] Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing.<ref>PMID:8626664</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Lau DKW]]
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[[Category: McIntosh LP]]
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[[Category: Okon M]]

Current revision

Solution Structure of ETS Transcription Factor PU.1

PDB ID 5w3g

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