1xnr

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (06:19, 3 April 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1xnr.gif|left|200px]]
 
-
{{Structure
+
==Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center==
-
|PDB= 1xnr |SIZE=350|CAPTION= <scene name='initialview01'>1xnr</scene>, resolution 3.10&Aring;
+
<StructureSection load='1xnr' size='340' side='right'caption='[[1xnr]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=I:INOSINIC+ACID'>I</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
<table><tr><td colspan='2'>[[1xnr]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XNR FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PAR:PAROMOMYCIN'>PAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xnr OCA], [https://pdbe.org/1xnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xnr RCSB], [https://www.ebi.ac.uk/pdbsum/1xnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xnr ProSAT]</span></td></tr>
-
|RELATEDENTRY=[[1xnq|1XNQ]], [[1xmo|1XMO]], [[1xmq|1XMQ]], [[1ibl|1IBL]]
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xnr OCA], [http://www.ebi.ac.uk/pdbsum/1xnr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xnr RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/RS2_THET8 RS2_THET8] Spans the head-body hinge region of the 30S subunit. Is loosely associated with the 30S subunit.[HAMAP-Rule:MF_00291_B]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xn/1xnr_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xnr ConSurf].
 +
<div style="clear:both"></div>
-
'''Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center'''
+
==See Also==
-
 
+
*[[Ribosomal protein THX 3D structures|Ribosomal protein THX 3D structures]]
-
 
+
*[[Ribosome 3D structures|Ribosome 3D structures]]
-
==Overview==
+
*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
-
Here we report the crystal structures of I.C and I.A wobble base pairs in the context of the ribosomal decoding center, clearly showing that the I.A base pair is of an I(anti).A(anti) conformation, as predicted by Crick. Additionally, the structures enable the observation of changes in the anticodon to allow purine-purine base pairing, the 'widest' base pair geometry allowed in the wobble position.
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Large Structures]]
-
1XNR is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNR OCA].
+
-
 
+
-
==Reference==
+
-
Structure of a purine-purine wobble base pair in the decoding center of the ribosome., Murphy FV 4th, Ramakrishnan V, Nat Struct Mol Biol. 2004 Dec;11(12):1251-2. Epub 2004 Nov 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15558050 15558050]
+
-
[[Category: Protein complex]]
+
[[Category: Thermus thermophilus]]
[[Category: Thermus thermophilus]]
-
[[Category: Murphy, F V.]]
+
[[Category: Murphy FV]]
-
[[Category: Ramakrishnan, V.]]
+
[[Category: Ramakrishnan V]]
-
[[Category: 30]]
+
-
[[Category: decoding]]
+
-
[[Category: ribosome]]
+
-
[[Category: translation]]
+
-
[[Category: trna modification]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:52:10 2008''
+

Current revision

Crystal Structure of an Inosine-Cytosine Wobble Base Pair in the Context of the Decoding Center

PDB ID 1xnr

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xnr"
Personal tools