5xwm
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human ERp44 zinc-bound form== | |
| - | + | <StructureSection load='5xwm' size='340' side='right'caption='[[5xwm]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5xwm]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XWM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XWM FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xwm OCA], [https://pdbe.org/5xwm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xwm RCSB], [https://www.ebi.ac.uk/pdbsum/5xwm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xwm ProSAT]</span></td></tr> |
| - | [[Category: Harayama | + | </table> |
| - | [[Category: Watanabe | + | == Function == |
| + | [https://www.uniprot.org/uniprot/ERP44_HUMAN ERP44_HUMAN] Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.<ref>PMID:11847130</ref> <ref>PMID:14517240</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Harayama M]] | ||
| + | [[Category: Inaba K]] | ||
| + | [[Category: Watanabe S]] | ||
Current revision
human ERp44 zinc-bound form
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