5xze

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m (Protected "5xze" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xze is ON HOLD until Paper Publication
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==Mouse cGAS bound to the inhibitor RU332==
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<StructureSection load='5xze' size='340' side='right'caption='[[5xze]], [[Resolution|resolution]] 2.18&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xze]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XZE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.177&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE7:(3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one'>AE7</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xze OCA], [https://pdbe.org/5xze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xze RCSB], [https://www.ebi.ac.uk/pdbsum/5xze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xze ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
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Authors: Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D.J., Glickman, J.F., Ascano, M.
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==See Also==
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*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
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Description: Mouse cGAS bound to the inhibitor RU332
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__TOC__
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[[Category: Unreleased Structures]]
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</StructureSection>
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[[Category: Patel, D.J]]
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[[Category: Large Structures]]
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[[Category: Tuschl, T]]
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[[Category: Mus musculus]]
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[[Category: Aida, J]]
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[[Category: Adura C]]
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[[Category: Glickman, J.F]]
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[[Category: Aida J]]
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[[Category: Reasoner, S]]
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[[Category: Asano Y]]
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[[Category: Ascano, M]]
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[[Category: Ascano M]]
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[[Category: Okamoto, R]]
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[[Category: Aso K]]
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[[Category: Aso, K]]
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[[Category: Gao P]]
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[[Category: Gao, P]]
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[[Category: Glickman JF]]
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[[Category: Gogakos, T]]
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[[Category: Gogakos T]]
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[[Category: Asano, Y]]
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[[Category: Imaeda T]]
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[[Category: Vincent, J]]
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[[Category: Lama L]]
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[[Category: Adura, C]]
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[[Category: Luz A]]
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[[Category: Rothamel, K]]
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[[Category: Okamoto R]]
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[[Category: Lama, L]]
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[[Category: Patel DJ]]
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[[Category: Steinberg, J]]
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[[Category: Reasoner S]]
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[[Category: Luz, A]]
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[[Category: Rothamel K]]
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[[Category: Imaeda, T]]
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[[Category: Steinberg J]]
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[[Category: Tuschl T]]
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[[Category: Vincent J]]

Current revision

Mouse cGAS bound to the inhibitor RU332

PDB ID 5xze

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OCA

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