This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5xzg

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5xzg is ON HOLD until Paper Publication Authors: Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., R...)
Current revision (14:16, 13 March 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5xzg is ON HOLD until Paper Publication
+
==Mouse cGAS bound to the inhibitor RU521==
 +
<StructureSection load='5xzg' size='340' side='right'caption='[[5xzg]], [[Resolution|resolution]] 1.83&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5xzg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5XZG FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.828&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AEV:2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one'>AEV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5xzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xzg OCA], [https://pdbe.org/5xzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5xzg RCSB], [https://www.ebi.ac.uk/pdbsum/5xzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5xzg ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
-
Authors: Vincent, J., Adura, C., Gao, P., Luz, A., Lama, L., Asano, Y., Okamoto, R., Imaeda, T., Aida, J., Rothamel, K., Gogakos, T., Steinberg, J., Reasoner, S., Aso, K., Tuschl, T., Patel, D.J., Glickman, J.F., Ascano, M.
+
==See Also==
-
 
+
*[[Cyclic GMP-AMP synthase 3D synthase|Cyclic GMP-AMP synthase 3D synthase]]
-
Description: Mouse cGAS bound to the inhibitor RU521
+
__TOC__
-
[[Category: Unreleased Structures]]
+
</StructureSection>
-
[[Category: Patel, D.J]]
+
[[Category: Large Structures]]
-
[[Category: Tuschl, T]]
+
[[Category: Mus musculus]]
-
[[Category: Aida, J]]
+
[[Category: Adura C]]
-
[[Category: Glickman, J.F]]
+
[[Category: Aida J]]
-
[[Category: Reasoner, S]]
+
[[Category: Asano Y]]
-
[[Category: Ascano, M]]
+
[[Category: Ascano M]]
-
[[Category: Okamoto, R]]
+
[[Category: Aso K]]
-
[[Category: Aso, K]]
+
[[Category: Gao P]]
-
[[Category: Gao, P]]
+
[[Category: Glickman JF]]
-
[[Category: Gogakos, T]]
+
[[Category: Gogakos T]]
-
[[Category: Asano, Y]]
+
[[Category: Imaeda T]]
-
[[Category: Vincent, J]]
+
[[Category: Lama L]]
-
[[Category: Adura, C]]
+
[[Category: Luz A]]
-
[[Category: Rothamel, K]]
+
[[Category: Okamoto R]]
-
[[Category: Lama, L]]
+
[[Category: Patel DJ]]
-
[[Category: Steinberg, J]]
+
[[Category: Reasoner S]]
-
[[Category: Luz, A]]
+
[[Category: Rothamel K]]
-
[[Category: Imaeda, T]]
+
[[Category: Steinberg J]]
 +
[[Category: Tuschl T]]
 +
[[Category: Vincent J]]

Current revision

Mouse cGAS bound to the inhibitor RU521

PDB ID 5xzg

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5xzg"
Personal tools