1xpx

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[[Image:1xpx.gif|left|200px]]
 
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{{Structure
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==Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells==
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|PDB= 1xpx |SIZE=350|CAPTION= <scene name='initialview01'>1xpx</scene>, resolution 2.80&Aring;
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<StructureSection load='1xpx' size='340' side='right'caption='[[1xpx]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
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<table><tr><td colspan='2'>[[1xpx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XPX FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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|GENE= pros ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpx OCA], [https://pdbe.org/1xpx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xpx RCSB], [https://www.ebi.ac.uk/pdbsum/1xpx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xpx ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xpx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xpx OCA], [http://www.ebi.ac.uk/pdbsum/1xpx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xpx RCSB]</span>
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[https://www.uniprot.org/uniprot/PROS_DROME PROS_DROME] Required for proper neuronal differentiation of most or all neurons and their precursors in central and peripheral nervous systems, axonal outgrowth and pathfinding. Not required for the specification of neuronal identity. May regulate transcription by binding to DNA.<ref>PMID:1720353</ref> <ref>PMID:1842358</ref> <ref>PMID:1540176</ref> <ref>PMID:11051550</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xp/1xpx_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The crystal structure of a complex between the novel homeodomain of the neural transcription factor Prospero and DNA shows that the invariant residues Lys1290, Asn1294, and Asp1297 make specific contacts with the noncanonical DNA binding site. The overall structure includes the homeodomain and the adjacent Prospero domain and confirms that they act as a single structural unit, a Homeo-Prospero domain. The Prospero domain facilitates the proper alignment of the protein on the DNA. Knowledge of the structure reconciles two different DNA sequences that have been proposed as transcriptional targets for Prospero. As in the apo structure, the C terminus of the Prospero domain shields a short helix within the homeodomain that includes a nuclear export signal (NES). The structural results suggest that exposure of the NES is not coupled directly to DNA binding. We propose a DNA recognition mechanism specific to Prospero-type homeodomains in developing cells.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xpx ConSurf].
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1XPX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XPX OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Structural basis of Prospero-DNA interaction: implications for transcription regulation in developing cells., Yousef MS, Matthews BW, Structure. 2005 Apr;13(4):601-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15837198 15837198]
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__TOC__
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</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Matthews, B W.]]
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[[Category: Matthews BW]]
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[[Category: Yousef, M S.]]
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[[Category: Yousef MS]]
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[[Category: homeodomain]]
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[[Category: neural cell development]]
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[[Category: prospero]]
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[[Category: protein-dna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:53:00 2008''
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Current revision

Structural basis of prospero-DNA interaction; implications for transcription regulation in developing cells

PDB ID 1xpx

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