5y6f

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'''Unreleased structure'''
 
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The entry 5y6f is ON HOLD until Paper Publication
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==Crystal structure of YcgR in complex with c-di-GMP from Escherichia coli==
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<StructureSection load='5y6f' size='340' side='right'caption='[[5y6f]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Hou, Y.J., Wang, D.C., Li, D.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5y6f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y6F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y6F FirstGlance]. <br>
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Description: Crystal structure of YcgR in complex with c-di-GMP from Escherichia coli
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C2E:9,9-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d 3,2-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)'>C2E</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Wang, D.C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y6f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y6f OCA], [https://pdbe.org/5y6f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y6f RCSB], [https://www.ebi.ac.uk/pdbsum/5y6f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y6f ProSAT]</span></td></tr>
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[[Category: Hou, Y.J]]
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</table>
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[[Category: Li, D.F]]
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== Function ==
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[https://www.uniprot.org/uniprot/YCGR_ECOLI YCGR_ECOLI] Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)-dependent manner. When bound to c-di-GMP it binds to elements of the flagellar motor (MotA (PubMed:20303158) and/or FliG and FliM (PubMed:20346719), binding to FliM also occurs in the absence of c-di-GMP), causing the motor to slow down. Thus, increasing levels of c-di-GMP lead to decreased motility. Probably binds 1 c-di-GMP dimer per subunit.<ref>PMID:11031114</ref> <ref>PMID:16920715</ref> <ref>PMID:20303158</ref> <ref>PMID:20346719</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Escherichia coli K-12]]
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[[Category: Large Structures]]
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[[Category: Hou YJ]]
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[[Category: Li DF]]
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[[Category: Wang DC]]

Current revision

Crystal structure of YcgR in complex with c-di-GMP from Escherichia coli

PDB ID 5y6f

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