5y9e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HPV58 pentamer== | |
| + | <StructureSection load='5y9e' size='340' side='right'caption='[[5y9e]], [[Resolution|resolution]] 2.04Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5y9e]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_58 Human papillomavirus 58]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y9E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.042Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9e OCA], [https://pdbe.org/5y9e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y9e RCSB], [https://www.ebi.ac.uk/pdbsum/5y9e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/VL1_HPV58 VL1_HPV58] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]<ref>PMID:12610160</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Li | + | __TOC__ |
| - | [[Category: Li | + | </StructureSection> |
| + | [[Category: Human papillomavirus 58]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Li SW]] | ||
| + | [[Category: Li ZH]] | ||
Current revision
Crystal structure of HPV58 pentamer
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