5y9o
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The apo structure of Legionella pneumophila WipA== |
| + | <StructureSection load='5y9o' size='340' side='right'caption='[[5y9o]], [[Resolution|resolution]] 2.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5y9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Y9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Y9O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.554Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5y9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5y9o OCA], [https://pdbe.org/5y9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5y9o RCSB], [https://www.ebi.ac.uk/pdbsum/5y9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5y9o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q5GA16_LEGPN Q5GA16_LEGPN] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The gram-negative bacterium Legionella pneumophila invades human's lung and causes Legionnaires' disease. To benefit its survival and replication in cellular milieu, L. pneumophila secrets at least 330 effector proteins into host cells. We found that the effector WipA has the protein tyrosine phosphatase (PTP) activity but does not depend on the classical CX5R motif for activity, suggesting that WipA is an unconventional PTP. Meanwhile, the presence of three other highly conserved motifs typically seen in protein serine/threonine phosphatases and the poor inhibition of WipA activity by okadaic acid led us to propose that WipA is a bacterial protein phosphatase. In addition, the determination of the 2.55-A crystal structure of WipA revealed that WipA resembles cold-active protein tyrosine phosphatase (CAPTPase), and therefore very likely shares the same catalytic mechanism. | ||
| - | + | Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity.,Jia Q, Lin Y, Gou X, He L, Shen D, Chen D, Xie W, Lu Y Acta Biochim Biophys Sin (Shanghai). 2018 Apr 26. pii: 4986413. doi:, 10.1093/abbs/gmy042. PMID:29701815<ref>PMID:29701815</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5y9o" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Legionella pneumophila]] | ||
| + | [[Category: Jia Q]] | ||
| + | [[Category: Xie W]] | ||
Current revision
The apo structure of Legionella pneumophila WipA
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