6anu

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 6anu is ON HOLD until Paper Publication Authors: Wang, F., Orlova, A., Avery, A.W., Hays, T.S., Egelman, E.H. Description: Cryo-EM structure of F-a...)
Current revision (14:17, 13 March 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6anu is ON HOLD until Paper Publication
+
==Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain==
 +
<SX load='6anu' size='340' side='right' viewer='molstar' caption='[[6anu]], [[Resolution|resolution]] 7.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[6anu]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ANU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ANU FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7&#8491;</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6anu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6anu OCA], [https://pdbe.org/6anu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6anu RCSB], [https://www.ebi.ac.uk/pdbsum/6anu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6anu ProSAT]</span></td></tr>
 +
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:[https://omim.org/entry/607371 607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.<ref>PMID:16685646</ref> Defects in ACTB are the cause of Baraitser-Winter syndrome type 1 (BRWS1) [MIM:[https://omim.org/entry/243310 243310]. A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.<ref>PMID:22366783</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
-
Authors: Wang, F., Orlova, A., Avery, A.W., Hays, T.S., Egelman, E.H.
+
==See Also==
-
 
+
*[[Actin 3D structures|Actin 3D structures]]
-
Description: Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain
+
*[[Spectrin 3D structures|Spectrin 3D structures]]
-
[[Category: Unreleased Structures]]
+
== References ==
-
[[Category: Avery, A.W]]
+
<references/>
-
[[Category: Egelman, E.H]]
+
__TOC__
-
[[Category: Wang, F]]
+
</SX>
-
[[Category: Hays, T.S]]
+
[[Category: Homo sapiens]]
-
[[Category: Orlova, A]]
+
[[Category: Large Structures]]
 +
[[Category: Avery AW]]
 +
[[Category: Egelman EH]]
 +
[[Category: Hays TS]]
 +
[[Category: Orlova A]]
 +
[[Category: Wang F]]

Current revision

Cryo-EM structure of F-actin complexed with the beta-III-spectrin actin-binding domain

6anu, resolution 7.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6anu"
Personal tools