6ap9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6ap9 is ON HOLD until Paper Publication Authors: Kumari, V., Ji, X. Description: Crystal Structure of hGSTP1-1 with S-nitrosation of Cys101 [[Categ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of hGSTP1-1 with S-nitrosation of Cys101== | |
| + | <StructureSection load='6ap9' size='340' side='right'caption='[[6ap9]], [[Resolution|resolution]] 1.55Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ap9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AP9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GDS:OXIDIZED+GLUTATHIONE+DISULFIDE'>GDS</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SNC:S-NITROSO-CYSTEINE'>SNC</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ap9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ap9 OCA], [https://pdbe.org/6ap9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ap9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ap9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ap9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GSTP1_HUMAN GSTP1_HUMAN] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.<ref>PMID:21668448</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: Ji | + | __TOC__ |
| - | [[Category: Kumari | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ji X]] | ||
| + | [[Category: Kumari V]] | ||
Current revision
Crystal Structure of hGSTP1-1 with S-nitrosation of Cys101
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