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6avu

From Proteopedia

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'''Unreleased structure'''
 
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The entry 6avu is ON HOLD
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==Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609==
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<SX load='6avu' size='340' side='right' viewer='molstar' caption='[[6avu]], [[Resolution|resolution]] 35.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6avu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AVU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 35&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6avu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6avu OCA], [https://pdbe.org/6avu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6avu RCSB], [https://www.ebi.ac.uk/pdbsum/6avu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6avu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ITAV_HUMAN ITAV_HUMAN] The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
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Authors: Borst, A.J., James, Z.N., Zagotta, W.N., Ginsberg, M., Rey, F.A., DiMaio, F., Backovic, M., Veesler, D.
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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Description: Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609
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*[[Integrin 3D structures|Integrin 3D structures]]
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[[Category: Unreleased Structures]]
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__TOC__
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[[Category: Backovic, M]]
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</SX>
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[[Category: Veesler, D]]
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[[Category: Homo sapiens]]
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[[Category: Zagotta, W.N]]
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[[Category: Large Structures]]
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[[Category: James, Z.N]]
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[[Category: Mus musculus]]
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[[Category: Ginsberg, M]]
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[[Category: Backovic M]]
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[[Category: Borst, A.J]]
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[[Category: Borst AJ]]
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[[Category: Rey, F.A]]
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[[Category: DiMaio F]]
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[[Category: Dimaio, F]]
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[[Category: Ginsberg M]]
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[[Category: James ZN]]
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[[Category: Rey FA]]
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[[Category: Veesler D]]
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[[Category: Zagotta WN]]

Current revision

Human alpha-V beta-3 Integrin (open conformation) in complex with the therapeutic antibody LM609

6avu, resolution 35.00Å

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OCA

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