6aw4
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==1.50A resolution structure of catechol O-methyltransferase (COMT) from Nannospalax galili== | |
| + | <StructureSection load='6aw4' size='340' side='right'caption='[[6aw4]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6aw4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nannospalax_galili Nannospalax galili]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AW4 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6aw4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6aw4 OCA], [https://pdbe.org/6aw4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6aw4 RCSB], [https://www.ebi.ac.uk/pdbsum/6aw4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6aw4 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A452CSQ0_NANGA A0A452CSQ0_NANGA] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.[ARBA:ARBA00003256] | ||
| - | + | ==See Also== | |
| - | + | *[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Nannospalax galili]] |
| - | [[Category: | + | [[Category: Battaile KP]] |
| - | [[Category: | + | [[Category: Deng Y]] |
| - | [[Category: Lovell | + | [[Category: Hanzlik RP]] |
| - | [[Category: | + | [[Category: Lovell S]] |
| - | [[Category: | + | [[Category: Mehzabeen N]] |
| + | [[Category: Moskovitz J]] | ||
| + | [[Category: Shams I]] | ||
Current revision
1.50A resolution structure of catechol O-methyltransferase (COMT) from Nannospalax galili
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