6awn

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(New page: '''Unreleased structure''' The entry 6awn is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures)
Current revision (08:56, 9 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6awn is ON HOLD until Paper Publication
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==X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site==
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<StructureSection load='6awn' size='340' side='right'caption='[[6awn]], [[Resolution|resolution]] 3.62&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6awn]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6AWN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6AWN FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.62&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8PR:PAROXETINE'>8PR</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6awn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6awn OCA], [https://pdbe.org/6awn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6awn RCSB], [https://www.ebi.ac.uk/pdbsum/6awn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6awn ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A0A0F7R1P3_MOUSE A0A0F7R1P3_MOUSE]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Selective serotonin reuptake inhibitors are clinically prescribed antidepressants that act by increasing the local concentrations of neurotransmitters at synapses and in extracellular spaces via blockade of the serotonin transporter. Here we report X-ray structures of engineered thermostable variants of the human serotonin transporter bound to the antidepressants sertraline, fluvoxamine, and paroxetine. The drugs prevent serotonin binding by occupying the central substrate-binding site and stabilizing the transporter in an outward-open conformation. These structures explain how residues within the central site orchestrate binding of chemically diverse inhibitors and mediate transporter drug selectivity.
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Authors:
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Structural basis for recognition of diverse antidepressants by the human serotonin transporter.,Coleman JA, Gouaux E Nat Struct Mol Biol. 2018 Feb;25(2):170-175. doi: 10.1038/s41594-018-0026-8. Epub, 2018 Jan 29. PMID:29379174<ref>PMID:29379174</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 6awn" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[Serotonin Transporter|Serotonin Transporter]]
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*[[3D structures of non-human antibody|3D structures of non-human antibody]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Coleman JA]]
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[[Category: Gouaux E]]

Current revision

X-ray structure of the S439T human serotonin transporter complexed with paroxetine at the central site

PDB ID 6awn

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