1xxq

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[[Image:1xxq.gif|left|200px]]
 
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{{Structure
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==Structure of a mannose-specific jacalin-related lectin from Morus nigra==
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|PDB= 1xxq |SIZE=350|CAPTION= <scene name='initialview01'>1xxq</scene>, resolution 1.80&Aring;
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<StructureSection load='1xxq' size='340' side='right'caption='[[1xxq]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1xxq]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxq OCA], [https://pdbe.org/1xxq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxq RCSB], [https://www.ebi.ac.uk/pdbsum/1xxq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxq ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1xxr|1XXR]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxq OCA], [http://www.ebi.ac.uk/pdbsum/1xxq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xxq RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q8LGR3_MORNI Q8LGR3_MORNI]
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== Evolutionary Conservation ==
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'''Structure of a mannose-specific jacalin-related lectin from Morus nigra'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxq_consurf.spt"</scriptWhenChecked>
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The structures of MornigaM and the MornigaM-mannose complex have been determined at 1.8 A and 2.0 A resolution, respectively. Both structures adopt the typical beta-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbohydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure-function relationships within the small group of Moraceae lectins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XXQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXQ OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxq ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose., Rabijns A, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Rouge P, FEBS J. 2005 Jul;272(14):3725-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16008570 16008570]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Morus nigra]]
[[Category: Morus nigra]]
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[[Category: Single protein]]
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[[Category: Barre A]]
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[[Category: Barre, A.]]
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[[Category: De Ranter CJ]]
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[[Category: Damme, E J.M Van.]]
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[[Category: Peumans WJ]]
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[[Category: Peumans, W J.]]
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[[Category: Rabijns A]]
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[[Category: Rabijns, A.]]
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[[Category: Rouge P]]
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[[Category: Ranter, C J.De.]]
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[[Category: Van Damme EJM]]
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[[Category: Rouge, P.]]
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[[Category: jacalin-fold]]
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[[Category: tetrameric b-prism fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:56:02 2008''
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Current revision

Structure of a mannose-specific jacalin-related lectin from Morus nigra

PDB ID 1xxq

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