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1xxr

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[[Image:1xxr.gif|left|200px]]
 
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{{Structure
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==Structure of a mannose-specific jacalin-related lectin from Morus Nigra in complex with mannose==
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|PDB= 1xxr |SIZE=350|CAPTION= <scene name='initialview01'>1xxr</scene>, resolution 2.00&Aring;
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<StructureSection load='1xxr' size='340' side='right'caption='[[1xxr]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1xxr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXR FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxr OCA], [https://pdbe.org/1xxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxr RCSB], [https://www.ebi.ac.uk/pdbsum/1xxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxr ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1xxq|1XXQ]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxr OCA], [http://www.ebi.ac.uk/pdbsum/1xxr PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xxr RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q8LGR3_MORNI Q8LGR3_MORNI]
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== Evolutionary Conservation ==
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'''Structure of a mannose-specific jacalin-related lectin from Morus Nigra in complex with mannose'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxr_consurf.spt"</scriptWhenChecked>
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The structures of MornigaM and the MornigaM-mannose complex have been determined at 1.8 A and 2.0 A resolution, respectively. Both structures adopt the typical beta-prism motif found in other jacalin-related lectins and their tetrameric assembly closely resembles that of jacalin. The carbohydrate-binding cavity of MornigaM readily binds mannose. No major structural rearrangements can be observed in MornigaM upon binding of mannose. These results allow corroboration of the structure-function relationships within the small group of Moraceae lectins.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1XXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Morus_nigra Morus nigra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXR OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxr ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural analysis of the jacalin-related lectin MornigaM from the black mulberry (Morus nigra) in complex with mannose., Rabijns A, Barre A, Van Damme EJ, Peumans WJ, De Ranter CJ, Rouge P, FEBS J. 2005 Jul;272(14):3725-32. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16008570 16008570]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Morus nigra]]
[[Category: Morus nigra]]
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[[Category: Single protein]]
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[[Category: Barre A]]
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[[Category: Barre, A.]]
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[[Category: De Ranter CJ]]
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[[Category: Damme, E J.M Van.]]
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[[Category: Peumans WJ]]
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[[Category: Peumans, W J.]]
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[[Category: Rabijns A]]
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[[Category: Rabijns, A.]]
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[[Category: Rouge P]]
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[[Category: Ranter, C J.De.]]
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[[Category: Van Damme EJM]]
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[[Category: Rouge, P.]]
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[[Category: tetrameric b-prism fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:56:06 2008''
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Current revision

Structure of a mannose-specific jacalin-related lectin from Morus Nigra in complex with mannose

PDB ID 1xxr

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