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1xxo

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[[Image:1xxo.gif|left|200px]]
 
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{{Structure
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==X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolution==
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|PDB= 1xxo |SIZE=350|CAPTION= <scene name='initialview01'>1xxo</scene>, resolution 1.80&Aring;
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<StructureSection load='1xxo' size='340' side='right'caption='[[1xxo]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1xxo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XXO FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= RV1155 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxo OCA], [https://pdbe.org/1xxo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xxo RCSB], [https://www.ebi.ac.uk/pdbsum/1xxo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xxo ProSAT], [https://www.topsan.org/Proteins/TBSGC/1xxo TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=pfam01243 Pyridox_oxidase]</span>
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</table>
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|RELATEDENTRY=[[1axj|1AXJ]], [[1g76|1G76]], [[1y30|1Y30]], [[2aq6|2AQ6]]
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xxo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xxo OCA], [http://www.ebi.ac.uk/pdbsum/1xxo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1xxo RCSB]</span>
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[https://www.uniprot.org/uniprot/F420R_MYCTU F420R_MYCTU] F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo (PubMed:27364382). Binds coenzyme F420, but does not bind FMN or other flavins (PubMed:25644473). Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'-phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates (PubMed:25644473).<ref>PMID:25644473</ref> <ref>PMID:27364382</ref>
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xx/1xxo_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xxo ConSurf].
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<div style="clear:both"></div>
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'''X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolution'''
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==See Also==
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*[[Pyridoxine 5'-phosphate oxidase|Pyridoxine 5'-phosphate oxidase]]
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== References ==
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==About this Structure==
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<references/>
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1XXO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XXO OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Biswal BK]]
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[[Category: Biswal, B K.]]
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[[Category: Cherney MM]]
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[[Category: Cherney, M M.]]
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[[Category: Garen C]]
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[[Category: Garen, C.]]
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[[Category: James MNG]]
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[[Category: James, M N.G.]]
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[[Category: Wang M]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Wang, M.]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: pyridoxine 5'-phosphate]]
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[[Category: structural genomic]]
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[[Category: tb structural genomics consortium]]
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[[Category: tbsgc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:56:03 2008''
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Current revision

X-ray crystal structure of mycobacterium tuberculosis pyridoxine 5'-phosphate oxidase at 1.8 a resolution

PDB ID 1xxo

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