6b1g

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m (Protected "6b1g" [edit=sysop:move=sysop])
Current revision (07:29, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6b1g is ON HOLD
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==Solution structure of TDP-43 N-terminal domain dimer.==
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<StructureSection load='6b1g' size='340' side='right'caption='[[6b1g]]' scene=''>
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Authors: Naik, M.T., Wang, A., Conicella, A., Fawzi, N.L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6b1g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B1G FirstGlance]. <br>
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Description: Solution structure of TDP-43 N-terminal domain dimer.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b1g OCA], [https://pdbe.org/6b1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b1g RCSB], [https://www.ebi.ac.uk/pdbsum/6b1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b1g ProSAT]</span></td></tr>
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[[Category: Conicella, A]]
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</table>
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[[Category: Wang, A]]
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== Disease ==
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[[Category: Fawzi, N.L]]
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[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] Defects in TARDBP are the cause of amyotrophic lateral sclerosis type 10 (ALS10) [MIM:[https://omim.org/entry/612069 612069]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of ALS is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases.<ref>PMID:20740007</ref> <ref>PMID:18288693</ref> <ref>PMID:18438952</ref> <ref>PMID:18396105</ref> <ref>PMID:18372902</ref> <ref>PMID:18309045</ref> <ref>PMID:19350673</ref> <ref>PMID:19224587</ref> <ref>PMID:19655382</ref> <ref>PMID:19695877</ref> <ref>PMID:21220647</ref> <ref>PMID:21418058</ref> <ref>PMID:22456481</ref>
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[[Category: Naik, M.T]]
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== Function ==
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[https://www.uniprot.org/uniprot/TADBP_HUMAN TADBP_HUMAN] DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR.<ref>PMID:17481916</ref> <ref>PMID:11285240</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Conicella A]]
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[[Category: Fawzi NL]]
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[[Category: Naik MT]]
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[[Category: Wang A]]

Current revision

Solution structure of TDP-43 N-terminal domain dimer.

PDB ID 6b1g

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