6b1z
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Glutamate-tRNA Synthetase from Elizabethkingia anophelis== | |
| + | <StructureSection load='6b1z' size='340' side='right'caption='[[6b1z]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6b1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Elizabethkingia_anophelis Elizabethkingia anophelis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B1Z FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b1z OCA], [https://pdbe.org/6b1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b1z RCSB], [https://www.ebi.ac.uk/pdbsum/6b1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b1z ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A077E909_9FLAO A0A077E909_9FLAO] Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).[HAMAP-Rule:MF_00022] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Elizabethkingia bacteria are globally emerging pathogens that cause opportunistic and nosocomial infections, with up to 40% mortality among the immunocompromised. Elizabethkingia species are in the pipeline of organisms for high-throughput structural analysis at the Seattle Structural Genomics Center for Infectious Disease (SSGCID). These efforts include the structure-function analysis of potential therapeutic targets. Glutamyl-tRNA synthetase (GluRS) is essential for tRNA aminoacylation and is under investigation as a bacterial drug target. The SSGCID produced, crystallized and determined high-resolution structures of GluRS from E. meningosepticum (EmGluRS) and E. anopheles (EaGluRS). EmGluRS was co-crystallized with glutamate, while EaGluRS is an apo structure. EmGluRS shares approximately 97% sequence identity with EaGluRS but less than 39% sequence identity with any other structure in the Protein Data Bank. EmGluRS and EaGluRS have the prototypical bacterial GluRS topology. EmGluRS and EaGluRS have similar binding sites and tertiary structures to other bacterial GluRSs that are promising drug targets. These structural similarities can be exploited for drug discovery. | ||
| - | + | Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum.,Brooks L, Subramanian S, Dranow DM, Mayclin SJ, Myler PJ, Asojo OA Acta Crystallogr F Struct Biol Commun. 2022 Aug 1;78(Pt 8):306-312. doi: , 10.1107/S2053230X22007555. Epub 2022 Jul 28. PMID:35924598<ref>PMID:35924598</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 6b1z" style="background-color:#fffaf0;"></div> |
| + | |||
| + | ==See Also== | ||
| + | *[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Elizabethkingia anophelis]] | ||
| + | [[Category: Large Structures]] | ||
Current revision
Crystal Structure of Glutamate-tRNA Synthetase from Elizabethkingia anophelis
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