6b30
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6b30 is ON HOLD Authors: Skene, R.J., Hoffman, I. Description: Structure of RORgt in complex with a novel inverse agonist 1 [[Category: Unreleased ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of RORgt in complex with a novel inverse agonist 1== | |
| - | + | <StructureSection load='6b30' size='340' side='right'caption='[[6b30]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6b30]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6B30 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6B30 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CFG:N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide'>CFG</scene></td></tr> |
| - | [[Category: Hoffman | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6b30 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6b30 OCA], [https://pdbe.org/6b30 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6b30 RCSB], [https://www.ebi.ac.uk/pdbsum/6b30 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6b30 ProSAT]</span></td></tr> |
| - | [[Category: Skene | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hoffman I]] | ||
| + | [[Category: Skene RJ]] | ||
Current revision
Structure of RORgt in complex with a novel inverse agonist 1
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