1y17

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[[Image:1y17.gif|left|200px]]
 
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{{Structure
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==crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus==
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|PDB= 1y17 |SIZE=350|CAPTION= <scene name='initialview01'>1y17</scene>, resolution 2.40&Aring;
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<StructureSection load='1y17' size='340' side='right'caption='[[1y17]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>
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<table><tr><td colspan='2'>[[1y17]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y17 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y17 OCA], [https://pdbe.org/1y17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y17 RCSB], [https://www.ebi.ac.uk/pdbsum/1y17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y17 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1wt9|1wt9]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1y17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y17 OCA], [http://www.ebi.ac.uk/pdbsum/1y17 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1y17 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/SLAA_DEIAC SLAA_DEIAC] Anticoagulant protein which binds to the gamma-carboxyglutamic acid-domain regions of factors IX and factor X in the presence of calcium with a 1 to 1 stoichiometry. Also inhibits platelet aggregation by binding to platelet glycoprotein Ibalpha (GP1BA) and functioning as a blocker of vWF. Is devoid of hemorrhagic and lethal activities. Possess antithrombotic and thrombolytic activities. Also hydrolyzes the Aalpha-chain of fibrinogen. Does not affect the Bbeta-chain and the gamma chain (By similarity).
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== Evolutionary Conservation ==
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'''crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y17_consurf.spt"</scriptWhenChecked>
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1Y17 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Deinagkistrodon_acutus Deinagkistrodon acutus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y17 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y17 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Deinagkistrodon acutus]]
[[Category: Deinagkistrodon acutus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Liang, Z.]]
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[[Category: Liang Z]]
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[[Category: Liu, S.]]
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[[Category: Liu S]]
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[[Category: Mo, X.]]
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[[Category: Mo X]]
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[[Category: Niu, L.]]
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[[Category: Niu L]]
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[[Category: Teng, M.]]
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[[Category: Teng M]]
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[[Category: Yu, X.]]
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[[Category: Yu X]]
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[[Category: Zang, J.]]
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[[Category: Zang J]]
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[[Category: Zhao, W.]]
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[[Category: Zhao W]]
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[[Category: Zhu, Z.]]
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[[Category: Zhu Z]]
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[[Category: aa-x-bp-ii]]
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[[Category: agkistrodon acutus]]
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[[Category: c-type lectin-like protein]]
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[[Category: snake venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 00:57:31 2008''
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Current revision

crystal structure of Aa-X-bp-II, a snake venom protein with the activity of binding to coagulation factor X from Agkistrodon acutus

PDB ID 1y17

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