RNA ligase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' scene='RNA_ligase/Cv/1' caption='Se-Met RNA ligase (PDB code [[1vgj]])'> |
| - | '''RNA ligase''' (LigR) is an enzyme which ligates two ribonucleotide chains using ATP and producing AMP, diphosphate and the ligated ribonucleotide chain<ref>PMID:18972386</ref>. See more details in [[T4 RNA ligase 2 (Rnl2)]] and [[Ligases]]. | + | '''RNA ligase''' (LigR) is an enzyme which ligates two ribonucleotide chains using ATP and producing AMP, diphosphate and the ligated ribonucleotide chain<ref>PMID:18972386</ref>. '''RNA ligase RtcB''' joins 2',3'-cyclic phosphate and 5'-OH ends<ref>PMID:21757685</ref>. See more details in [[T4 RNA ligase 2 (Rnl2)]] and [[Ligases]]. |
</StructureSection> | </StructureSection> | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *RNA ligase | + | * RNA ligase |
**[[2c5u]] – T4LigR 1 RNA-binding domain - Enterobacteria phage T4<br /> | **[[2c5u]] – T4LigR 1 RNA-binding domain - Enterobacteria phage T4<br /> | ||
**[[1s68]] - T4LigR 2 N-terminal<br /> | **[[1s68]] - T4LigR 2 N-terminal<br /> | ||
| - | **[[1vgj]], [[1vdx]] – | + | **[[1vgj]], [[1vdx]] – PhLigR – ''Pyrococcus horikoshii''<br /> |
| + | **[[8dcg]] – PhLigR RtcB <br /> | ||
**[[2vug]] – LigR – ''Pyrococcus abyssi''<br /> | **[[2vug]] – LigR – ''Pyrococcus abyssi''<br /> | ||
| - | **[[5cot]] – NgLigR – ''Naegleria gruberi''<br /> | ||
**[[1xdn]] – LigR 1 editing – ''Trypanosoma brucei''<br /> | **[[1xdn]] – LigR 1 editing – ''Trypanosoma brucei''<br /> | ||
**[[1iuh]] – LigR 2’-5’ – ''Thermus thermophilus''<br /> | **[[1iuh]] – LigR 2’-5’ – ''Thermus thermophilus''<br /> | ||
**[[5cot]] – aLigR – amoeba<br /> | **[[5cot]] – aLigR – amoeba<br /> | ||
| + | **[[6vt0]], [[6vt1]], [[6vt3]], [[6vt4]], [[6vt5]], [[6vtg]], [[5cov]] – aLigR (mutant) <br /> | ||
* RNA ligase complex | * RNA ligase complex | ||
| + | **[[7p3b]] – hLigR RtcB + GMP + Co - human<br /> | ||
**[[5tt6]] – T4LigR 1 + ATP<br /> | **[[5tt6]] – T4LigR 1 + ATP<br /> | ||
**[[2hvr]], [[2hvs]] – T4LigR 2 + DNA + nucleotide <br /> | **[[2hvr]], [[2hvs]] – T4LigR 2 + DNA + nucleotide <br /> | ||
**[[2hvq]] - T4LigR 2 + adenosine derivative<br /> | **[[2hvq]] - T4LigR 2 + adenosine derivative<br /> | ||
**[[4qak]] - LigR 2’-5’ + AMP – ''Escherichia coli''<br /> | **[[4qak]] - LigR 2’-5’ + AMP – ''Escherichia coli''<br /> | ||
| - | **[[5cou]] – aLigR + ATP<br /> | + | **[[5cou]], [[6vt6]], [[6vt8]], [[6vt9]], [[6vtb]], [[6vtd]] – aLigR (mutant) + ATP<br /> |
| + | **[[6vte]] – aLigR (mutant) + AMP<br /> | ||
| + | **[[6vtf]] – aLigR + pyrophosphate<br /> | ||
**[[5d1o]], [[5d1p]] – LigR ATP-dependent + ATP – ''Methanothermobacter thermautotrophicus''<br /> | **[[5d1o]], [[5d1p]] – LigR ATP-dependent + ATP – ''Methanothermobacter thermautotrophicus''<br /> | ||
| - | **[[4isz]] – PhLigR RtcB + GTP + | + | **[[4isz]], [[8dc9]], [[8dca]], [[8dcb]], [[8dcd]], [[8dcf]] – PhLigR RtcB + GTP + ion<br /> |
**[[4dwq]], [[4it0]] – PhLigR RtcB + GMP + Mn<br /> | **[[4dwq]], [[4it0]] – PhLigR RtcB + GMP + Mn<br /> | ||
**[[4isj]], [[4dwr]] – PhLigR RtcB + Mn<br /> | **[[4isj]], [[4dwr]] – PhLigR RtcB + Mn<br /> | ||
| - | **[[ | + | **[[7lfq]] – PhLigR RtcB + DNA<br /> |
| - | + | ||
}} | }} | ||
== References == | == References == | ||
Current revision
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3D Structures of RNA ligase
Updated on 05-November-2023
References
- ↑ Nichols NM, Tabor S, McReynolds LA. RNA ligases. Curr Protoc Mol Biol. 2008 Oct;Chapter 3:Unit3.15. doi:, 10.1002/0471142727.mb0315s84. PMID:18972386 doi:http://dx.doi.org/10.1002/0471142727.mb0315s84
- ↑ Tanaka N, Meineke B, Shuman S. RtcB, a novel RNA ligase, can catalyze tRNA splicing and HAC1 mRNA splicing in vivo. J Biol Chem. 2011 Sep 2;286(35):30253-30257. PMID:21757685 doi:10.1074/jbc.C111.274597
