5ygm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: '''Unreleased structure''' The entry 5ygm is ON HOLD until Sep 24 2019 Authors: Park, J.H., Park, Y.R., Lee, S.J. Description: Monomeric structure of concanavalin A at pH 7.5 from Carn...)
Current revision (08:29, 22 November 2023) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 5ygm is ON HOLD until Sep 24 2019
+
==Monomeric structure of concanavalin A at pH 7.5 from Carnivalia ensiformis==
 +
<StructureSection load='5ygm' size='340' side='right'caption='[[5ygm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[5ygm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Canavalia_ensiformis Canavalia ensiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5YGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5YGM FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ygm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ygm OCA], [https://pdbe.org/5ygm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ygm RCSB], [https://www.ebi.ac.uk/pdbsum/5ygm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ygm ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CONA_CANBR CONA_CANBR] Glucose/D-mannose specific lectin. Has anti-inflammatory activity in rats. Induces histamine release in mast cells from hamster and rat. Induces lymphocyte proliferation and IFNG production. Shows toxicity against the aquatic snail B.glabrata at concentrations higher than 20 ug/ml.<ref>PMID:1398779</ref> <ref>PMID:7524287</ref> <ref>PMID:8891754</ref> <ref>PMID:18472821</ref> <ref>PMID:9575151</ref> <ref>PMID:10747944</ref> <ref>PMID:19765980</ref>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structure of concanavalin A (ConA) has been studied intensively due to its specific interactions with carbohydrates and its heterometal (Ca2+ and Mn2+) coordination. Most structures from X-ray crystallography have shown ConA as a dimer or tetramer, because the complex formation requires specific crystallization conditions. Here, we reported a monomeric structure of ConA with a resolution of 1.6 A, which revealed that metal coordination could trigger sugar binding ability. The calcium coordination residue, Asn14, changes the orientation of carbohydrate binding residues and biophysical details, including structural information, providing valuable clues for the development and application of detection kits using ConA.
-
Authors: Park, J.H., Park, Y.R., Lee, S.J.
+
Heterometal-coordinated monomeric concanavalin A at pH 7.5 from Canavalia ensiformis.,Chung NJ, Park YR, Lee DH, Park JH, Lee SJ J Microbiol Biotechnol. 2017 Oct 13. doi: 10.4014/jmb.1709.09057. PMID:29025256<ref>PMID:29025256</ref>
-
Description: Monomeric structure of concanavalin A at pH 7.5 from Carnivalia ensiformis
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Lee, S.J]]
+
<div class="pdbe-citations 5ygm" style="background-color:#fffaf0;"></div>
-
[[Category: Park, Y.R]]
+
 
-
[[Category: Park, J.H]]
+
==See Also==
 +
*[[Concanavalin 3D structures|Concanavalin 3D structures]]
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Canavalia ensiformis]]
 +
[[Category: Large Structures]]
 +
[[Category: Lee SJ]]
 +
[[Category: Park JH]]
 +
[[Category: Park YR]]

Current revision

Monomeric structure of concanavalin A at pH 7.5 from Carnivalia ensiformis

PDB ID 5ygm

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ygm"
Personal tools