6ej0
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of KDM5B in complex with KDOPZ000049a.== | |
| + | <StructureSection load='6ej0' size='340' side='right'caption='[[6ej0]], [[Resolution|resolution]] 2.06Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6ej0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EJ0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6EJ0 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B7K:7-oxidanylidene-6-propan-2-yl-5-[1-(1-prop-2-enoylpiperidin-4-yl)pyrazol-4-yl]-6~{H}-pyrazolo[1,5-a]pyrimidine-3-carbonitrile'>B7K</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ej0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ej0 OCA], [http://pdbe.org/6ej0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ej0 RCSB], [http://www.ebi.ac.uk/pdbsum/6ej0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ej0 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Lysine-specific histone demethylase 3D structures|Lysine-specific histone demethylase 3D structures]] | |
| - | + | *[[Retinoblastoma-binding protein 3D structures|Retinoblastoma-binding protein 3D structures]] | |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith, C H]] | ||
| + | [[Category: Bountra, C]] | ||
| + | [[Category: Burgess-Brown, N A]] | ||
| + | [[Category: Delft, F von]] | ||
| + | [[Category: Edwards, A]] | ||
[[Category: Huber, K]] | [[Category: Huber, K]] | ||
| - | [[Category: | + | [[Category: Kupinska, K]] |
| - | [[Category: | + | [[Category: Newman, J A]] |
[[Category: Oppermann, U]] | [[Category: Oppermann, U]] | ||
| + | [[Category: Ruda, G F]] | ||
| + | [[Category: Srikannathasan, V]] | ||
| + | [[Category: Strain-Damerell, C]] | ||
[[Category: Szykowska, A]] | [[Category: Szykowska, A]] | ||
| - | + | [[Category: Vazquez-Rodriguez, S A]] | |
| - | + | ||
| - | [[Category: Vazquez-Rodriguez, S | + | |
| - | + | ||
| - | + | ||
| - | + | ||
[[Category: Wright, M]] | [[Category: Wright, M]] | ||
| - | [[Category: | + | [[Category: Kdm5b lysine specific demethylase]] |
| - | [[Category: | + | [[Category: Oxidoreductase]] |
| - | + | ||
Current revision
Crystal structure of KDM5B in complex with KDOPZ000049a.
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Categories: Large Structures | Arrowsmith, C H | Bountra, C | Burgess-Brown, N A | Delft, F von | Edwards, A | Huber, K | Kupinska, K | Newman, J A | Oppermann, U | Ruda, G F | Srikannathasan, V | Strain-Damerell, C | Szykowska, A | Vazquez-Rodriguez, S A | Wright, M | Kdm5b lysine specific demethylase | Oxidoreductase
