5mhc

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==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
==Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide==
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<StructureSection load='5mhc' size='340' side='right' caption='[[5mhc]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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<StructureSection load='5mhc' size='340' side='right'caption='[[5mhc]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5mhc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5MHC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5mhc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5MHC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5MHC FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5mhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhc OCA], [http://pdbe.org/5mhc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5mhc RCSB], [http://www.ebi.ac.uk/pdbsum/5mhc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5mhc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5mhc OCA], [https://pdbe.org/5mhc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5mhc RCSB], [https://www.ebi.ac.uk/pdbsum/5mhc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5mhc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
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[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5mhc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5mhc" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Andrei, S]]
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[[Category: Homo sapiens]]
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[[Category: Leysen, S]]
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[[Category: Large Structures]]
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[[Category: Ottmann, C]]
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[[Category: Andrei S]]
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[[Category: 14-3-3 p53 c-terminus]]
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[[Category: Leysen S]]
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[[Category: Antitumor protein]]
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[[Category: Ottmann C]]

Current revision

Crystal structure of 14-3-3sigma and a p53 C-terminal 12-mer synthetic phosphopeptide

PDB ID 5mhc

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