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5u6k

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==Crystal structure of TopBP1 BRCT4/5 in complex with a BLM phosphopeptide==
==Crystal structure of TopBP1 BRCT4/5 in complex with a BLM phosphopeptide==
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<StructureSection load='5u6k' size='340' side='right' caption='[[5u6k]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='5u6k' size='340' side='right'caption='[[5u6k]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5u6k]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U6K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5U6K FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5u6k]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5U6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5U6K FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5u6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u6k OCA], [http://pdbe.org/5u6k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5u6k RCSB], [http://www.ebi.ac.uk/pdbsum/5u6k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5u6k ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5u6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5u6k OCA], [https://pdbe.org/5u6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5u6k RCSB], [https://www.ebi.ac.uk/pdbsum/5u6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5u6k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TOPB1_MOUSE TOPB1_MOUSE]] Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity).[UniProtKB:Q92547]<ref>PMID:14718568</ref>
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[https://www.uniprot.org/uniprot/TOPB1_MOUSE TOPB1_MOUSE] Required for DNA replication (By similarity). Plays a role in the rescue of stalled replication forks and checkpoint control (PubMed:14718568). Binds double-stranded DNA breaks and nicks as well as single-stranded DNA (By similarity). Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage (By similarity). Induces a large increase in the kinase activity of ATR (By similarity).[UniProtKB:Q92547]<ref>PMID:14718568</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5u6k" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5u6k" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Topoisomerase binding protein|Topoisomerase binding protein]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Edwards, R A]]
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[[Category: Homo sapiens]]
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[[Category: Glover, J N.M]]
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[[Category: Large Structures]]
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[[Category: Sun, L]]
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[[Category: Mus musculus]]
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[[Category: Brct repeat family replication checkpoint control peptide bound protein complex]]
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[[Category: Edwards RA]]
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[[Category: Peptide binding protein]]
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[[Category: Glover JNM]]
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[[Category: Sun L]]

Current revision

Crystal structure of TopBP1 BRCT4/5 in complex with a BLM phosphopeptide

PDB ID 5u6k

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